Initiation, Synapsis and Joining Mechanisms of IgH Class Switch Recombination

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Air date:	Wednesday, January 3, 2007, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 125 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	01:11:04
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The broad focus of Dr. Alt’s laboratory is the elucidation of mechanisms involved in maintenance of genomic stability in mammalian cells. More specifically, his laboratory studies the mechanism and control of antigen receptor variable region gene assembly (VDJ recombination) in developing B and T lymphocytes and the mechanism of immunoglobulin heavy chain class switch recombination (CSR) and somatic hypermutation in activated mature B lymphocytes. Studies of the regulation of these processes involve elucidation of signaling events that lead to their activation, as well as elucidation of cis-acting chromosomal processes that effect accessibility. Some studies employ biochemical approaches to elucidate molecular mechanisms by which the RAG endonuclease (RAG) and Activation Induced Deaminase (AID) function on DNA to initiate, respectively, VDJ recombination and CSR. Immunology Interest Group

NLM Title:	Initiation, synapsis, and joining mechanisms of IgH class switch recombination / Fred Alt.
Author:	Alt, Frederick W. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): The broad focus of Dr. Alt's laboratory is the elucidation of mechanisms involved in maintenance of genomic stability in mammalian cells. More specifically, his laboratory studies the mechanism and control of antigen receptor variable region gene assembly (VDJ recombination) in developing B and T lymphocytes and the mechanism of immunoglobulin heavy chain class switch recombination (CSR) and somatic hypermutation in activated mature B lymphocytes. Studies of the regulation of these processes involve elucidation of signaling events that lead to their activation, as well as elucidation of cis-acting chromosomal processes that effect accessibility. Some studies employ biochemical approaches to elucidate molecular mechanisms by which the RAG endonuclease (RAG) and Activation Induced Deaminase (AID) function on DNA to initiate, respectively, VDJ recombination and CSR. Immunology Interest Group.
Subjects:	Cytidine Deaminase--physiology Immunoglobulin Class Switching--physiology Immunoglobulin Switch Region
Publication Types:	Lecture Webcast
NLM Classification:	QW 541
NLM ID:	101298636
CIT Live ID:	5307
Permanent link:	https://videocast.nih.gov/watch=5307

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