Skip Navigation

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Hormone-Dependent Neurocircuits Optimize Activity and Skeletal Health in Females

Loading video...

219 Views

Air date: Monday, January 27, 2020, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 219 (51 Live, 168 On-demand)
Category: Neuroscience
Runtime: 00:54:40
Description: NIH Neuroscience Series Seminar

Estrogen triggers profound metabolic and behavioral responses to optimize female physiology. Dr Ingraham’s lab seeks to discover crucial hormone-responsive nodes in the brain and gut that maintain metabolic, skeletal, and cognitive health in female mice. Findings from their basic science research program are highly relevant to women's health.

An ongoing project is aimed at understanding a remarkable increase in bone density after manipulating hypothalamic neurons (Herber, Krause et al, 2019). They suspect that a novel, anabolic factor is responsible for these dense, strong bones. With new funding from NIA, they will determine how the female brain controls bone metabolism and identify this anabolic bone factor for potential treatment of osteoporosis in both sexes.

In another project, they recently explain how surges in estrogen prior to the period of sexual receptivity increase physical activity in females (Krause et al 2019). It follows that metabolic health declines when this activity node goes "off-line" after natural or drug-induced menopause. With new funding from NIDDK, they wish to exploit this discovery to overcome declining health and physical activity associated with hormone-depletion.

In a new project funded by NINDS and the RAININ Foundation, they wish to determine whether gut-brain signaling pathways exhibit sex-specific differences, an important question that may relate to the higher prevalence of intestinal visceral pain syndromes experienced by women.

For more information go to https://neuroscience.nih.gov/neuroseries
Author: Holly Ingraham, Ph.D., University of California, San Francisco
 
CIT Live ID: 35375
Permanent link: https://videocast.nih.gov/watch=35375

Related Videos...

Click Here to Play Video.
05:57:43
Science of Mind-Body Interactions - an Exploration of Integrative Mechanisms (Day 1)
[Conferences]
3/26/2001
Click Here to Play Video.
08:08:59
Asymptomatic Primary Hyperparathyroidism, A Perspective for the 21st Century (Day 1)
[Conferences]
4/8/2002
Click Here to Play Video.
06:54:26
Third North American Symposium on Skeletal Complications of Malignancy (Day 2)
[Conferences]
4/26/2002
Click Here to Play Video.
07:08:56
Menopausal Hormone Therapy Day 1
[Conferences]
10/23/2002
Click Here to Play Video.
03:32:48
Science in the Public Health: Diet and Weight Control - Hold the Bun? (HHS-Only)
[STEP (HHS Only)]
2/8/2005
Click Here to Play Video.
07:21:09
Office of Research on Women's Health Symposium on Family Hormonal Health
[Women's Health]
10/29/2004
Click Here to Play Video.
03:45:07
Aging Well: It's Better than the Alternatives (HHS Only)
[STEP (HHS Only)]
3/6/2007
Click Here to Play Video.
03:34:39
Science in the Public Health - I've Got Rhythm, Circadian Rhythm!
[STEP (HHS Only)]
3/5/2009
Click Here to Play Video.
06:54:15
NIH Consensus Development Conference: Lactose Intolerance and Health - Day 1
[Conferences]
2/22/2010
Click Here to Play Video.
01:32:46
Update on Myofascial Pain Syndrome: Translating the Evidence to Improve Outcomes through Physical Medicine and Rehabilitation
[Women's Health]
8/6/2010