NIH VideoCast - Interleukin 35 (IL-35) and IL-35-producing Regulatory B Cells (i35-Bregs): Critical Regulators of Autoimmune Diseases.

Skip Navigation

Interleukin 35 (IL-35) and IL-35-producing Regulatory B Cells (i35-Bregs): Critical Regulators of Autoimmune Diseases.

Loading... Loading video...

346 Views

Air date:	Wednesday, February 24, 2016, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 346 (51 Live, 295 On-demand)
Category:	Immunology
Runtime:	01:00:47
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Immunology Interest Group Charles E. Egwuagu is Chief of the Molecular Immunology Section, National Eye Institute (NEI), NIH. He received his Ph.D in Epidemiology and Microbiology from Yale University Graduate School and a Master of Public Health (M.P.H) degree in Infectious Disease Epidemiology from Yale School of Medicine, New Haven, Connecticut. Dr. Egwuagu did a 2-year Post-doctoral Fellowship in Molecular Immunology at NEI/NIH and then served as a Commissioned Officer of the United States Public Health Service (PHS) for 10 years, attaining the rank of Captain (06). Research in the Egwuagu laboratory is on autoreactive lymphocytes that mediate CNS autoimmune diseases, such as Uveitis and Multiple Sclerosis. Focus is on cytokine signaling with particular interest in the roles of JAK/STAT pathway and suppressors of cytokine signaling (SOCS) proteins in the regulation of lymphocyte development and cell-fate decisions. Beginning with his seminal finding that susceptibility or resistance to organ-specific autoimmune disease is inversely correlated with expression level of the relevant autoantigen in the thymus, his work evolved towards characterization of lymphocyte subsets that mediate uveitis. These studies culminated in an important paper in Nature Medicine showing that Th17 cells mediate uveitis and are inhibited in the neuroretina by Interleukin 27 (IL-27). More recently his lab discovered a novel regulatory B cell population that produces IL-35 (i35-Breg) and now pioneering the use of adoptive Breg/i35-Breg therapy for organ-specific autoimmune diseases. Dr. Egwuagu is a recipient of The United States Public Health Service Commendation Medal, Howard Hughes Medical Institute/NIH Scholar Program Mentoring Award and is a Standing Member of the CMIA (Cellular & Molecular Immunology-A) NIH Study Section. Abstract: Seminar will focus on the immunobiology of Interleukin 35 (IL-35), our discovery of a novel regulatory B cell population that produces IL-35 (i35-Breg) and pioneering work on the use of IL-35 and adoptive Breg/i35-Breg therapy for organ-specific autoimmune diseases. Seminar will conclude with recent data addressing the question of whether Breg constitutes a unique B cell lineage or merely peripheral B cells that are induced to produce regulatory cytokines during inflammation, akin to inducible Tregs.

NLM Title:	Interleukin 35 (IL-35) and iL-35-producing regulatory B cells (i35-Bregs) : critical regulators of autoimmune diseases / Charles E. Egwuagu.
Author:	Egwuagu, Charles. National Institutes of Health (U.S.). Immunology Interest Group,
Publisher:
Abstract:	(CIT): Lecture will focus on the immunobiology of Interleukin 35 (IL-35), our discovery of a novel regulatory B cell population that produces IL-35 (i35-Breg) and pioneering work on the use of IL-35 and adoptive Breg/i35-Breg therapy for organ-specific autoimmune diseases. Lecture will conclude with recent data addressing the question of whether Breg constitutes a unique B cell lineage or merely peripheral B cells that are induced to produce regulatory cytokines during inflammation, akin to inducible Tregs.
Subjects:	Autoimmune Diseases of the Nervous System--immunology B-Lymphocytes, Regulatory--immunology Interleukins--immunology
Publication Types:	Lecture Webcast

NLM Classification:	WL 140
NLM ID:	101678422
CIT Live ID:	18508
Permanent link:	https://videocast.nih.gov/watch=18508

Related Videos...