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Satisfying symmetry: uncovering functional insights from patterns in membrane protein structures

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Air date: Friday, April 5, 2019, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 94, (47 Live, 47 On-demand)
Category: NIH Director's Seminars
Runtime: 00:54:43
Description: NIH Director's Seminar Series

Proteins that are integral to the cellular membrane constitute around a third of the genome in any given organism. However, understanding of the mechanisms by which they function on the molecular level has lagged behind those of other macromolecules due to severe experimental challenges. Dr. Forrest will discuss computational strategies that have proved effective for predicting membrane protein structure and function, including uncovering an elegant role for symmetry in proteins responsible for solute transport across membranes.
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NLM Title: Satisfying symmetry : uncovering functional insights from patterns in membrane protein structures / Lucy R. Forrest.
Author: Forrest, Lucy R.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Seminar Series. Proteins that are integral to the cellular membrane constitute around a third of the genome in any given organism. However, understanding of the mechanisms by which they function on the molecular level has lagged behind those of other macromolecules due to severe experimental challenges. Dr. Forrest will discuss computational strategies that have proved effective for predicting membrane protein structure and function, including uncovering an elegant role for symmetry in proteins responsible for solute transport across membranes.
Subjects: Computational Biology--methods
Membrane Proteins--genetics
Membrane Proteins--ultrastructure
Protein Conformation
Publication Types: Lecture
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 55.7
NLM ID: 101746763
CIT Live ID: 31807
Permanent link: https://videocast.nih.gov/launch.asp?27426