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Dr. Crotty has made fundamental contributions to the study of vaccine responses, including studies that helped define factors contributing to vaccine effectiveness including establishing that follicular T helper cells are a distinct type of differentiated CD4 T cell uniquely specialized in B cell help. He will speak on T follicular helper cells (Tfh) and their control of B cell responses in the context of vaccines and infections.
Dr. Shane Crotty is an internationally recognized leader in the field of T follicular helper cells (Tfh cells) and vaccine biology. Dr. Crotty received a double B.S. in both Biology and Writing from the Massachusetts Institute of Technology (MIT) in 1996. During his PhD at UCSF, he discovered the mechanism of action of the antiviral drug ribavirin, a drug frequently used to treat chronic hepatitis C. In his postdoctoral work with Rafi Ahmed, Dr. Crotty went on to make seminal discoveries about germinal center formation, vaccine responses and the development of effective longterm antibodies. His work ranged from the demonstration of the role of the adaptor molecule SAP in germinal center formation, to studies on the duration of responses to small pox vaccination in humans. In 2003, he joined the faculty at the La Jolla Institute, where he has continued to make fundamental contributions to the study of vaccine responses, including studies that helped establish that Tfh cells are a distinct type of differentiated CD4 T cell uniquely specialized in B cell help, and that Tfh differentiation is controlled by the transcription factor Bcl6. His work has also helped characterize Tfh responses in humans during HIV infection and in response to vaccination. Dr. Crotty has been named a Pew Scholar and has received the American Association of Immunologists (AAI) B-D Investigator Award for outstanding early-career research contributions to the field of Immunology. Finally, he is also the author of Ahead of the Curve, a biography of Nobel laureate scientist David Baltimore, published in 2001, attesting to his wide-range of skills. His lecture will present some of his newest exciting findings on Tfh and B cell responses to vaccines.
Shane Crotty, Ph.D., Professor, Division of Vaccine Discovery, La Jolla Institute For Allergy and Immunology