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Redox Biology 2014 - NADPH Oxidase, Redox Imaging

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Air date: Tuesday, October 28, 2014, 4:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 77, (9 Live, 68 On-demand)
Category: Redox Biology
Runtime: 01:53:52
Description: Redox Biology

Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogenesis, angiogenesis and proliferation in animal models of cancer, and how NO alters patient imaging profiles and response to cancer therapy. It consists of two 1-hour lectures with ample time for discussion and analysis. The participation of postdoctoral and clinical fellows interested in redox biology is encouraged.

For more information go to http://ccr.cancer.gov/careers/courses/rb
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NLM Title: Redox biology 2014. NADPH oxidase. Redox imaging / T. Leto, Murali Krishna.
Author: Leto, Tom.
Krishna, Murali.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Recent advances in the biochemistry of redox-active species and radicals are beginning to be translated into improvements in prevention and treatment of cancer. Traditionally, reactive species such as superoxide, hydrogen peroxide and nitric oxide (NO) are associated with toxicity; however, NO is useful in the treatment of angina and cardiovascular disease. Also, NO is involved in cancer tumor angiogenesis and apoptosis of cancer cells. This course is an overview presenting how redox-active species and radicals are generated; their effects on the cellular and physiological level, how they alter carcinogenesis, angiogenesis and proliferation in animal models of cancer, and how NO alters patient imaging profiles and response to cancer therapy. It consists of two 1-hour lectures with ample time for discussion and analysis. The participation of postdoctoral and clinical fellows interested in redox biology is encouraged.
Subjects: Diagnostic Imaging
Immunity, Innate--immunology
NADPH Oxidases
Oxidation-Reduction
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QU 125
NLM ID: 101647946
CIT Live ID: 14610
Permanent link: https://videocast.nih.gov/launch.asp?18697