NIH VideoCast - WALS: Margaret Pittman Lecture- Cryptic (hidden) Changes that Result from Perturbations and Climate Change Shape Future Dynamics of Degenerate Neurons and Circuits

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WALS: Margaret Pittman Lecture- Cryptic (hidden) Changes that Result from Perturbations and Climate Change Shape Future Dynamics of Degenerate Neurons and Circuits

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Air date:	Wednesday, September 11, 2024, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 271 (192 Live, 79 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:00:45
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Eve Marder is a University Professor and the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. At Brandeis, Marder is also a member of the Volen National Center for Complex Systems. Dr. Marder is known for her pioneering work on small neuronal networks which her team has interrogated via a combination of complementary experimental and theoretical techniques. LECTURE SUMMARY: A fundamental problem in neuroscience is understanding how the properties of individual neurons and synapses contribute to neuronal circuit dynamics and behavior. In recent years we have done both computational and experimental studies that demonstrate that the same physiological output can arise from multiple, degenerate solutions, and that individual animals with similar behavior can nonetheless have quite different sets of underlying circuit parameters. Most recently, we have been studying the resilience of individual animals to perturbations such as temperature and high potassium concentrations. This has revealed that extreme environmental experiences can produce long-term changes in circuit performance that can be hidden, or “cryptic” unless the animals are again challenged or perturbed. Our present work is designed to understand differential resilience in natural, wild-caught animals in response to climate change, and shows long-lasting influences of the animals’ temperature history. For more information go to https://oir.nih.gov/wals/current-lecture-season

NLM Title:	Cryptic (hidden) changes that result from perturbations and climate change shape future dynamics of degenerate neurons and circuits / Eve Marder.
Author:	Marder, Eve. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Eve Marder is a University Professor and the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. At Brandeis, Marder is also a member of the Volen National Center for Complex Systems. Dr. Marder is known for her pioneering work on small neuronal networks which her team has interrogated via a combination of complementary experimental and theoretical techniques. LECTURE SUMMARY: A fundamental problem in neuroscience is understanding how the properties of individual neurons and synapses contribute to neuronal circuit dynamics and behavior. In recent years we have done both computational and experimental studies that demonstrate that the same physiological output can arise from multiple, degenerate solutions, and that individual animals with similar behavior can nonetheless have quite different sets of underlying circuit parameters. Most recently, we have been studying the resilience of individual animals to perturbations such as temperature and high potassium concentrations. This has revealed that extreme environmental experiences can produce long-term changes in circuit performance that can be hidden, or "cryptic" unless the animals are again challenged or perturbed. Our present work is designed to understand differential resilience in natural, wild-caught animals in response to climate change, and shows long-lasting influences of the animals" temperature history.For more information go to https://oir.nih.gov/wals/current-lecture-season.
Subjects:	Climate Change Environmental Exposure--adverse effects Long Term Adverse Effects Nerve Degeneration--etiology Nerve Degeneration--physiopathology Synaptic Transmission
Publication Types:	Lecture Webcast

NLM Classification:	WL 140
NLM ID:	9918916889706676
CIT Live ID:	55003
Permanent link:	https://videocast.nih.gov/watch=55003

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