Skip Navigation

CANCELLED - NIH-FDA Immunology Interest Group SeminarHHS Only

Air date: Wednesday, January 4, 2023, 4:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the targets of the E protein transcription factors control adaptive and innate lymphoid cell differentiation. Our recent studies led to the identification of ETS1 as a critical regulator of ID2 that promotes NK cell and ILC differentiation, and we are working toward an understanding of how ETS1 and ID2 cooperate to control NK cell maturation and effector function.

For more information go to https://www.niaid.nih.gov/research/immunology-seminars
Author: Barbara Kee
Runtime: 1 hour, 15 minutes