NIH VideoCast - Biomedical Engineering: Sex-specific in vitro models of aortic valve stenosis

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Biomedical Engineering: Sex-specific in vitro models of aortic valve stenosis

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Air date:	Tuesday, November 15, 2022, 1:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 127 (66 Live, 61 On-demand)
Category:	Special
Runtime:	01:00:03
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Biomedical Engineering Scientific Interest Group Cardiovascular disease is the leading cause of death in both men and women, yet our mechanistic knowledge of the sex-specific molecular and cellular mechanisms that guide cardiovascular disease progression, particularly in women, remain poorly characterized. Studies evaluating disease mechanisms rarely state the sex of cells used for in vitro studies or are performed primarily in male animal models, causing our gap in knowledge. My laboratory uses precision biomaterials as in vitro and in vivo tools to dissect mechanisms that contribute to sexual dimorphisms in cardiovascular diseases, specifically aortic valve stenosis. In my talk, I will discuss how we have used hydrogel biomaterials as engineered valve matrix mimics to explore sex dimorphisms in valvular interstitial cell phenotypes in vitro and describe sex-specific molecular mechanisms that may drive dimorphisms in aortic valve stenosis. Our work seeks to leverage biomaterial technologies to understand sex dimorphisms in health and disease, with the long-term goal of achieving sex and gender equity in cardiovascular disease treatments and outcomes. For more information go to https://oir.nih.gov/sigs/biomedical-engineering-scientific-interest-group

NLM Title:	Sex-specific in vitro models of aortic valve stenosis / Brian Aguado.
Author:	Aguado, Brian. National Institutes of Health (U.S.). Biomedical Engineering Scientific Interest Group,
Publisher:
Abstract:	(CIT): Biomedical Engineering Scientific Interest Group Cardiovascular disease is the leading cause of death in both men and women, yet our mechanistic knowledge of the sex-specific molecular and cellular mechanisms that guide cardiovascular disease progression, particularly in women, remain poorly characterized. Studies evaluating disease mechanisms rarely state the sex of cells used for in vitro studies or are performed primarily in male animal models, causing our gap in knowledge. My laboratory uses precision biomaterials as in vitro and in vivo tools to dissect mechanisms that contribute to sexual dimorphisms in cardiovascular diseases, specifically aortic valve stenosis. In my talk, I will discuss how we have used hydrogel biomaterials as engineered valve matrix mimics to explore sex dimorphisms in valvular interstitial cell phenotypes in vitro and describe sex-specific molecular mechanisms that may drive dimorphisms in aortic valve stenosis. Our work seeks to leverage biomaterial technologies to understand sex dimorphisms in health and disease, with the long-term goal of achieving sex and gender equity in cardiovascular disease treatments and outcomes.
Subjects:	Aortic Valve Stenosis Biomedical Engineering Models, Biological Sex Factors
Publication Types:	Lecture Webcast

NLM Classification:	WG 265
NLM ID:	9918573266206676
CIT Live ID:	48580
Permanent link:	https://videocast.nih.gov/watch=48580

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