NIH VideoCast - HEAL Workshop: Target Validation for Non-Addictive Therapeutics Development for Pain (DAY 2)

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HEAL Workshop: Target Validation for Non-Addictive Therapeutics Development for Pain (DAY 2)

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Air date:	Tuesday, October 20, 2020, 10:00:00 AM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 135 (14 Live, 121 On-demand)
Category:	Conferences
Runtime:	02:25:58
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Despite advances in the understanding of pain physiology there has been a paucity of novel analgesic medications developed to address the still high unmet need of pain patients especially those who rely on addictive opioid medicines for pain relief. The successful development of novel non-opioid, non-addictive therapeutics requires advances in preclinical target validation that demonstrate sufficient human disease relevance to trigger investment in non-clinical development and subsequent clinical trials to obtain proof of biology and early proof of efficacy before registrational studies. Translating novel target discoveries to the clinic depends on the quality of target validation and the rigorous implementation of research operating plans to provide compelling data supporting a causative link between the modulation of molecular target(s) and a disease phenotype associated with the disease state. The full target validation process covers target identification to proof-of concept efficacy in human subjects in clinical trials. This workshop will focus on the key preclinical experimental validation package components that de-risk and provide rigorous rationale for the pursuit of novel targets with minimal side effects and a reduced potential of abuse/addiction liability. The focus will be on the stage appropriate data required to justify further preclinical and clinical therapeutics development activities across the translational spectrum. Several perspectives will be presented including industry, academia, and venture capital. For more information go to https://meetings.ninds.nih.gov/Home/General/27810

NLM Title:	HEAL Workshop : Target Validation for Non-addictive Therapeutics Development for Pain / National Institute of Neurological Disorders and Stroke, NIH.
Author:	HEAL Workshop: Target Validation for Non-addictive Therapeutics Development for Pain National Institute of Neurological Disorders and Stroke (U.S.),
Publisher:
Abstract:	(CIT): Despite advances in the understanding of pain physiology there has been a paucity of novel analgesic medications developed to address the still high unmet need of pain patients especially those who rely on addictive opioid medicines for pain relief. The successful development of novel non-opioid, non-addictive therapeutics requires advances in preclinical target validation that demonstrate sufficient human disease relevance to trigger investment in non-clinical development and subsequent clinical trials to obtain proof of biology and early proof of efficacy before registrational studies. Translating novel target discoveries to the clinic depends on the quality of target validation and the rigorous implementation of research operating plans to provide compelling data supporting a causative link between the modulation of molecular target(s) and a disease phenotype associated with the disease state. The full target validation process covers target identification to proof-of concept efficacy in human subjects in clinical trials. This workshop will focus on the key preclinical experimental validation package components that de-risk and provide rigorous rationale for the pursuit of novel targets with minimal side effects and a reduced potential of abuse/addiction liability. The focus will be on the stage appropriate data required to justify further preclinical and clinical therapeutics development activities across the translational spectrum.
Subjects:	Analgesics--therapeutic use Behavior, Addictive--prevention & control Drug Discovery Molecular Targeted Therapy Pain--drug therapy
Publication Types:	Congress Webcast

NLM Classification:	WL 704
NLM ID:	101773043
CIT Live ID:	38866
Permanent link:	https://videocast.nih.gov/watch=38866

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