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NIH Director's Seminar - Phantoms in the transcriptome: post-transcriptional mRNA regulation through DNA and RNA modifications (NIH Only)

Air date: Friday, February 28, 2020, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Description: NIH Director's Seminar Series

Research in the Oberdoerffer laboratory examines how the epigenome and epitranscriptome act to expand the inherent coding potential of the human genome. With a specific focus on cytosine, the laboratory explores the role of DNA and RNA modifications in determining: 1) how a single gene generates multiple protein-coding variants, and 2) how a single messenger RNA (mRNA) molecule dictates distinct protein fates during the process of translation. Current investigations are centered on the mechanisms by which cytidine acetylation in mRNA regulates translation and the net impact on cellular function. In broad terms, the Oberdoerffer group aims at uncovering how cytosine modifications contribute to the etiology of disease and potentially identify avenues for novel therapeutic interventions.
Author: Shalini Oberdoerffer, Ph.D., Senior Investigator, Laboratory of Receptor Biology and Gene Expression, NCI, NIH
Runtime: 1 hour