NIH VideoCast - Cellular communication: how cells control who they’re talking to and what they’re saying

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Cellular communication: how cells control who they’re talking to and what they’re saying

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Air date:	Wednesday, December 6, 2017, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 267 (160 Live, 107 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:01:56
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Director's Wednesday Afternoon Lecture Series In multicellular organisms, a handful of intercellular communication pathways, such as Notch and BMP, play an outside role in controlling cell fate decisions. While we have much information about the specific molecules and interactions that comprise these pathways, we often understand little about the particular signal processing behaviors each pathway provides. We have been developing a ‘build-to-understand’ approach to this problem, reconstructing or re-wiring these pathways using synthetic biology approaches, and analyzing their dynamic behaviors at the level of individual cells. For his lecture, Dr. Elowitz will focus on a particular architectural feature in which a pathway uses multiple distinct ligand and receptor variants that interact promiscuously with one another. New results suggest how this apparent redundancy can, counterintuitively, allow control of signal specificity (“who talks to whom”) and target program (“message”). Dr. Elowitz will also discuss a new synthetic approach termed MEMOIR that should enable cells to record their own signaling histories over longer timescales. For more information go to https://oir.nih.gov/wals

Author:	Michael B. Elowitz, Ph.D., Professor of Biology, Bioengineering, and Applied Physics and Bren Scholar at the California Institute of Technology; Investigator, Howard Hughes Medical Institute

CIT Live ID:	26624
Permanent link:	https://videocast.nih.gov/watch=26624

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