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The primary shield: role of our microbes in heath and diseases

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Air date: Wednesday, April 26, 2017, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 575, (243 Live, 332 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:44:18
Description: NIH Director’s Wednesday Afternoon Lecture Series

The microbiota plays a fundamental role in the induction, education and function of the host immune system. In return, the host immune system has evolved multiple means by which to maintain its symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and the utilization of regulatory pathways involved in the sustained tolerance to innocuous antigens. The ability of microbes to set the immunological tone of tissues, both locally and systemically, requires tonic sensing of microbes and complex feedback loops between innate and adaptive components of the immune system. Dr. Belkaid will discuss some of the dominant mediators of these interactions and discuss emerging themes associated with our current understanding of the immunological dialogue between the host and its microbiota in health and diseases.

Dr. Belkaid work explores the field of immune regulation and has defined fundamental mechanisms that regulate tissue homeostasis and host immune responses. Her work uncovered key roles for the commensal microbiota and dietary factors in the maintenance of tissue immunity and protection to pathogens.
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NLM Title: The primary shield : role of our microbes in heath and diseases / Yasmine Belkaid.
Author: Belkaid, Yasmine.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series The microbiota plays a fundamental role in the induction, education and function of the host immune system. In return, the host immune system has evolved multiple means by which to maintain its symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and the utilization of regulatory pathways involved in the sustained tolerance to innocuous antigens. The ability of microbes to set the immunological tone of tissues, both locally and systemically, requires tonic sensing of microbes and complex feedback loops between innate and adaptive components of the immune system. Dr. Belkaid will discuss some of the dominant mediators of these interactions and discuss emerging themes associated with our current understanding of the immunological dialogue between the host and its microbiota in health and diseases. Dr. Belkaid work explores the field of immune regulation and has defined fundamental mechanisms that regulate tissue homeostasis and host immune responses. Her work uncovered key roles for the commensal microbiota and dietary factors in the maintenance of tissue immunity and protection to pathogens.
Subjects: Immune System--immunology
Immunity--immunology
Infections--immunology
Microbiota--immunology
Microbiota--physiology
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: QW 504
NLM ID: 101705367
CIT Live ID: 22147
Permanent link: https://videocast.nih.gov/watch=22147