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New antibiotics from the microbial dark matter

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Air date: Wednesday, February 15, 2017, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 370 (143 Live, 227 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 00:58:16
Description: NIH Director's Wednesday Afternoon Lecture Series

We are experiencing an antibiotic crisis: Our ability to discover novel compounds has diminished and pathogens go largely unchecked in acquiring and spreading resistance. The main source of antibiotics–soil actinomycetes–has been overmined. In chronic infections, the problem is compounded by the presence of dormant persister cells that are resistant to all antibiotics. As a result, chronic osteomyelitis or infections in patients with cystic fibrosis can be untreatable. About 99 percent of environmental microorganisms are uncultured. Dr. Lewis’s lab developed approaches for killing persister cells and growing uncultured bacteria. The lab found that this "microbial dark matter" harbors novel antimicrobials that evolved to be essentially free of resistance.

For more information go to https://oir.nih.gov/wals/2016-2017
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NLM Title: New antibiotics from the microbial dark matter / Kim Lewis.
Author: Lewis, Kim.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series. We are experiencing an antibiotic crisis: Our ability to discover novel compounds has diminished and pathogens go largely unchecked in acquiring and spreading resistance. The main source of antibiotics-soil actinomycetes-has been overmined. In chronic infections, the problem is compounded by the presence of dormant persister cells that are resistant to all antibiotics. As a result, chronic osteomyelitis or infections in patients with cystic fibrosis can be untreatable. About 99 percent of environmental microorganisms are uncultured. Dr. Lewis's lab developed approaches for killing persister cells and growing uncultured bacteria. The lab found that this "microbial dark matter" harbors novel antimicrobials that evolved to be essentially free of resistance.
Subjects: Anti-Bacterial Agents--therapeutic use
Drug Discovery
Drug Resistance, Bacterial
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: QV 350
NLM ID: 101702167
CIT Live ID: 21817
Permanent link: https://videocast.nih.gov/watch=21817