||NIDCR Clinical Research Fellowship Grand Rounds
Craniofacial abnormalities account for approximately one-third of all congenital birth defects, are a major cause of infant mortality, and dramatically impact national health care budgets. Postnatal treatment of malformation syndromes through comprehensive, well-coordinated and integrated strategies may provide satisfactory management of individual conditions, but rarely are they fully corrective. Therefore, considerable effort needs to be invested in developing prevention strategies, and this can only come from a thorough understanding of the normal events that regulate craniofacial development. The presentation will focus on recent advances in understanding the etiology and pathogenesis of Treacher Collins syndrome and emerging prospects for prevention that may have broad application to congenital craniofacial birth defects.