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The life of breath: the role of stem cells in lung maintenance and repair

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Air date: Wednesday, March 23, 2016, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 320, (109 Live, 211 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:02:46
Description: NIH Director’s Wednesday Afternoon Lecture Series

There have been recent exciting advances in our understanding of the stem and progenitor cells of the mammalian lung. Classic studies, including genetic lineage tracing experiments in the mouse using cell-specific Cre drivers, have shown relatively slow cell turnover and replacement of the respiratory epithelium at steady state. However, when cells are damaged by infection or toxic agents, quiescent progenitor populations are activated to promote repair. Injury models have also revealed evidence for an unexpected level of epithelial cell “plasticity” in which differentiated cells change their phenotype and give rise to either new stem cells or different cell types. Dr. Hogan’s lab uses clonal 3D in vitro organoid cultures to identify different populations of stem cells and the niche in which they reside, and to screen for factors promoting proliferation and differentiation at steady state and during injury-induced repair.

For more information go to https://oir.nih.gov/wals
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NLM Title: The life of breath : the role of stem cells in lung maintenance and repair / Brigid L. M. Hogan.
Author: Hogan, Brigid.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series. There have been recent exciting advances in our understanding of the stem and progenitor cells of the mammalian lung. Classic studies, including genetic lineage tracing experiments in the mouse using cell-specific Cre drivers, have shown relatively slow cell turnover and replacement of the respiratory epithelium at steady state. However, when cells are damaged by infection or toxic agents, quiescent progenitor populations are activated to promote repair. Injury models have also revealed evidence for an unexpected level of epithelial cell "plasticity" in which differentiated cells change their phenotype and give rise to either new stem cells or different cell types. Dr. Hogan's lab uses clonal 3D in vitro organoid cultures to identify different populations of stem cells and the niche in which they reside, and to screen for factors promoting proliferation and differentiation at steady state and during injury-induced repair.
Subjects: Cell Plasticity
Lung--cytology
Lung--physiology
Stem Cells
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WF 600
NLM ID: 101680597
CIT Live ID: 18712
Permanent link: https://videocast.nih.gov/watch=18712