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The NIH Director's Wednesday Afternoon Lecture Series
As human genetics has moved into the 21st century, tackling the genetics of complex, non-Mendelian disease has taken on greater prominence. Conventional linkage analysis and positional cloning methods, so successful in identifying over 1,000 genes for Mendelian traits, have had much more limited success when applied to complex diseases. Thus, attention has re-focused on association-based analysis as a potentially more powerful approach. To this end, major public and private efforts have centered on the large-scale identification of single nucleotide polymorphic (SNP) variation in the human genome.
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