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CRISPR-Cas genome surveillance: From basic biology to transformative technology

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Air date: Wednesday, March 11, 2015, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 1155, (383 Live, 772 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:05:13
Description: Wednesday Afternoon Lecture Series

Margaret Pittman Lecture

Dr. Doudna, who specializes in the study of RNA, will present a brief history of the bacterial RNA-guided CRISPR biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism. Using CRISPR-Cas (clustered regularly interspaced short palindromic repeats) technology provides the foundation for remarkable developments in modifying, regulating, or marking genomic loci in a wide variety of cells and organisms. These results highlight a new era in which genomic manipulation is no longer a bottleneck to experiments, paving the way to fundamental discoveries in biology with applications in all branches of biotechnology, and strategies for human therapeutics. Dr. Doudna will discuss recent findings regarding the molecular mechanism of Cas9 and its use for targeted cell-based therapies.

About the annual Margaret Pittman Lecture:
This annual lecture honors Dr. Margaret Pittman, NIH’s first female lab chief, who made significant contributions to microbiology and vaccine development, particularly in the areas of pertussis and tetanus, during her long career at the National Institute of Allergy and Infectious Diseases.

For more information go to http://wals.od.nih.gov
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NLM Title: CRISPR-Cas genome surveillance : from basic biology to transformative technology / Jennifer Doudna.
Author: Doudna, Jennifer A.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Dr. Doudna, who specializes in the study of RNA, will present a brief history of the bacterial RNA-guided CRISPR biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism. Using CRISPR-Cas (clustered regularly interspaced short palindromic repeats) technology provides the foundation for remarkable developments in modifying, regulating, or marking genomic loci in a wide variety of cells and organisms. These results highlight a new era in which genomic manipulation is no longer a bottleneck to experiments, paving the way to fundamental discoveries in biology with applications in all branches of biotechnology, and strategies for human therapeutics. Dr. Doudna will discuss recent findings regarding the molecular mechanism of Cas9 and its use for targeted cell-based therapies. About the annual Margaret Pittman Lecture: This annual lecture honors Dr. Margaret Pittman, NIH's first female lab chief, who made significant contributions to microbiology and vaccine development, particularly in the areas of pertussis and tetanus, during her long career at the National Institute of Allergy and Infectious Diseases.
Subjects: CRISPR-Cas Systems--genetics
RNA, Bacterial--genetics
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: QU 475
NLM ID: 101655816
CIT Live ID: 15743
Permanent link: https://videocast.nih.gov/watch=15743