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The Mechanotransduction Complex in Zebrafish Hair Cells

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Air date: Monday, April 28, 2014, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 219 (17 Live, 202 On-demand)
Category: Neuroscience
Runtime: 00:53:07
Description: Neuroscience Seminar Series

Dr. Nicolson’s lab is interested in the molecular basis of mechanotransduction and synaptic transmission in auditory/vestibular hair cells. To identify key players in these processes, they are studying zebrafish mutants with hearing and balance defects. The aim of their research is to determine gene function by examining the mutants at multiple levels, including the behavioral, cellular, and physiological levels. Another major goal is to provide animal models of human deafness.

Recently, they have concentrated their efforts on developing innovative ways of characterizing our mutants. These new techniques include quantitation of the vestibulo-ocular reflex, measuring post-synaptic responses to mechanical stimulation of hair cells, and calcium imaging of hair-cell transients using localized genetic indicators. With these tools in hand, they are able to gain a better understanding of gene function and apply their findings to understanding the pathology of congenital deafness in humans.
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NLM Title: The mechanotransduction complex in zebrafish hair cells / Teresa Nicolson.
Author: Nicolson, Teresa.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): Dr. Nicolson"s lab is interested in the molecular basis of mechanotransduction and synaptic transmission in auditory/vestibular hair cells. To identify key players in these processes, they are studying zebrafish mutants with hearing and balance defects. The aim of their research is to determine gene function by examining the mutants at multiple levels, including the behavioral, cellular, and physiological levels. Another major goal is to provide animal models of human deafness. Recently, they have concentrated their efforts on developing innovative ways of characterizing our mutants. These new techniques include quantitation of the vestibulo-ocular reflex, measuring post-synaptic responses to mechanical stimulation of hair cells, and calcium imaging of hair-cell transients using localized genetic indicators. With these tools in hand, they are able to gain a better understanding of gene function and apply their findings to understanding the pathology of congenital deafness in humans.
Subjects: Hair Cells, Auditory--physiology
Mechanotransduction, Cellular--genetics
Mutation
Zebrafish
Publication Types: Lecture
Webcast
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Caption Text: Download Caption File
NLM Classification: WV 250
NLM ID: 101631802
CIT Live ID: 13994
Permanent link: https://videocast.nih.gov/watch=13994