NIH VideoCast - WALS: Of Flies and Men – Harnessing the Power of Drosophila to Decipher the Molecular Mechanisms of Neurodegeneration

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WALS: Of Flies and Men – Harnessing the Power of Drosophila to Decipher the Molecular Mechanisms of Neurodegeneration

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Air date:	Wednesday, March 26, 2025, 2:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 296 (190 Live, 106 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	01:08:48
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The Zarnescu Laboratory studies the molecular mechanisms of aging and neurodegenerative diseases with a focus on RNA processing and cellular metabolism. We use a combination of molecular, genetic, bioinformatic and pharmacological tools, and a diverse array of experimental models, including fruit flies, cultured cells and patient tissues. We also seek to develop therapeutics for neurodegenerative disorders. For more information go to https://oir.nih.gov/wals/current-lecture-season

NLM Title:	Neurobiology of recovery after brain and spinal cord injury in macaque models / Tadashi Isa.
Author:	Isa, Tadashi. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Dr. Isa’s Lab aims at elucidating the neural circuit mechanisms for regulation of dexterous motor actions, learning, and the functional recovery after the brain and spinal cord injury. They are conducting the researches in various animal models for their goal, from mice, rats, marmosets, macaque monkeys, and humans, applying multidisciplinary methods, such as electrophysiology, psychophysics, neuroimaging, transgenic animals, viral vectors, and computational modeling. Dynamic properties of the large-scaled neural networks in the brain, which span multiple brain areas experience context-dependent transition in relation to the vigilance, attention or learning stage etc. One of the most typical situations where such transition occurs is during the functional recovery from the brain and/or spinal cord injury. They have been studying the neuronal mechanism of the post-lesion functional recovery and how the recovery is regulated by cognitive functions such as motivation. They believe that with this knowledge, they can develop effective therapeutic strategies to cure the brain/spinal cord injury in the future. A big progress in this field of research has recently been achieved by introduction of a new technique of pathway-selective and reversible manipulation technique using the combination of 2 viral vectors in monkeys, which was developed in Dr. Isa’s lab (Kinoshita et al. Nature 2012), by which they can pin-down the critical circuit(s) for recovery.
Subjects:	Brain Injuries--physiopathology Brain Injuries--rehabilitation Macaca Models, Animal Neural Pathways--physiology Spinal Cord Injuries--physiopathology Spinal Cord Injuries--rehabilitation
Publication Types:	Lecture Webcast

NLM Classification:	WL 354
NLM ID:	101771163
CIT Live ID:	55028
Permanent link:	https://videocast.nih.gov/watch=55028

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