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Bad deeds go unpunished: the vacuole guard hypothesis and pathogen intracellular growth

Air date: Wednesday, November 20, 2019, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
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Description: NIH Director’s Wednesday Afternoon Lecture Series

Ralph Isberg has been a Professor of Molecular Biology and Microbiology at Tufts University School of Medicine for 32 years. After receiving an undergraduate degree at Oberlin College, he obtained his PhD at Harvard working on transposable genetic elements in bacteria. Throughout his career at Tufts he has primarily focused on the pathogenesis of Legionella pneumophila and enteropathogenic Yersinia, and has recently initiated projects on tackling drug resistance in nosocomial organisms. His research highlights include the identification of proteins involved in uptake of bacteria into mammalian cells, the identification of the protein machine that allows Legionella to construct an intracellular niche, and understanding how innate immune recognition distinguishes pathogens from nonpathogens. He was elected a member of the National Academy of Sciences in 2009. Former trainees from his laboratory include some of the leading figures in the field of bacterial pathogenesis.

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Author: Ralph R. Isberg, Ph.D., Tufts University School of Medicine
Runtime: 1 hour