CIT can broadcast your seminar, conference or meeting live to a world-wide
audience over the Internet as a real-time streaming video. The event can
be recorded and made available for viewers to watch at their convenience
as an on-demand video or a downloadable file. CIT can also broadcast
NIH-only or HHS-only content.
Approximately 2 billion years ago, a poisonous gas emerged on Earth that wiped out most organisms and sent others deep underground. That gas was oxygen, O2, and within a geological wink of an eye, through processes poorly understood, oxygen gas levels rose from near zero to 20 percent of the atmosphere. The freely available oxygen gave way to the evolution of most visible life seen today.
Yet while oxygen is crucial for human life, too much will kill you. Breathing 100-percent oxygen for long periods damages the lungs and brain; and aging itself may be the result of slow oxygen poisoning, better known as oxidation and free-radical formation.
For this lecture in the Demystifying Medicine series, we bring you speakers who have seen the dangers of too little and too much oxygen. Mountaineer-scientist Louis Reichardt is the first American to have reached the summits of both Mt. Everest and K2 (only 200 meters shorter than Everest). Reichardt will present first-hand accounts of climbing without supplemental oxygen above the "death zone" of 8,000 meters and the subsequent risk of hallucinations, blurred vision, and loss of bodily functions.
Then we hear from our old friend Toren Finkel, who left the NIH in 2017 to become the director of the University of Pittsburgh Aging Institute. Finkel studies how oxygen metabolism, mitochondrial function, and autophagy regulate mammalian aging. His lab also is developing novel small molecules that may slow or even reverse aspects of aging and may therefore be of benefit for treating a wide array of age-related diseases.