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Decoding the genome regulatory program for T-cell identity

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Air date: Wednesday, June 27, 2018, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 336, (141 Live, 195 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:02:48
Description: NIH Director’s Wednesday Afternoon Lecture Series

T cells develop in the thymus from precursor cells that have migrated there while they still have the potential to give rise to multiple cell types. The decision of each precursor to become a T cell rather than another kind of cell is then established gradually in response to thymic environmental signals of Notch pathway activators and a limited set of growth factors. This multistep process involves a cascade of changes in the expression of different regulatory genes and resulting changes in global genome-wide activity. As the cells start their pathway to a T-cell fate, they come dangerously close to a gene-expression pattern typical of malignancy before they become safely locked into their T-cell identity. However, the developmental process is normally very effective at silencing the oncogenic genes at the right times as well as at endowing the cells with the qualities they will need to become useful T cells. When and how does this process resolve correctly and how does it reach a point of no return? Dr. Rothenberg’s lecture will present answers from the levels of gene-expression control, gene-regulatory networks, and dynamic single-cell imaging of the developmental process in real time.
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Author: Ellen V. Rothenberg, Ph.D., Albert Billings Ruddock Professor of Biology, California Institute of Technology
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CIT Live ID: 28006
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