NIH VideoCast - Epigenetics: How Genes and Environment Interact

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Epigenetics: How Genes and Environment Interact

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Air date:	Wednesday, April 18, 2012, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 3,144 (340 Live, 2,804 On-demand)
Category:	WALS - Wednesday Afternoon Lectures
Runtime:	00:58:00
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Human epidemiological and animal experimental data indicate that the risk of developing adult onset diseases and neurological disorders is influenced by persistent adaptations to prenatal and early postnatal environmental exposures. One group of epigenetically regulated genes that potentially links environmental exposures early in development to adult diseases are those with metastable epialleles. These genes have highly variable expression because of stochastic allelic changes in the epigenome rather than mutations in the genome. The viable yellow agouti (Avy) mouse harbors a metastable Agouti gene because of an upstream insertion of a transposable element. We have used the Avy mouse to investigate the importance of epigenetic alterations in determining adult disease risk in response to early developmental exposure to both chemical and physical agents. The importance these studies with regards to human health and disease will be discussed. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series

NLM Title:	Epigenetics : how genes and environment interact / Randy Jirtle.
Author:	Jirtle, Randy L. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Human epidemiological and animal experimental data indicate that the risk of developing adult onset diseases and neurological disorders is influenced by persistent adaptations to prenatal and early postnatal environmental exposures. One group of epigenetically regulated genes that potentially links environmental exposures early in development to adult diseases are those with metastable epialleles. These genes have highly variable expression because of stochastic allelic changes in the epigenome rather than mutations in the genome. The viable yellow agouti (Avy) mouse harbors a metastable Agouti gene because of an upstream insertion of a transposable element. We have used the Avy mouse to investigate the importance of epigenetic alterations in determining adult disease risk in response to early developmental exposure to both chemical and physical agents. The importance these studies with regards to human health and disease will be discussed. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
Subjects:	DNA Damage--genetics Environmental Exposure Epigenesis, Genetic--genetics
Publication Types:	Lecture Webcast

NLM Classification:	QU 477
NLM ID:	101585237
CIT Live ID:	10520
Permanent link:	https://videocast.nih.gov/watch=10520

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