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Optimal Use of Mice and Rats in Aging Research (Day 2)

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Air date: Wednesday, December 11, 2019, 9:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 120 (73 Live, 47 On-demand)
Category: Conferences
Runtime: 03:07:18
Description: Mice and rats have long been favorite animal models for aging research, because they are more closely related to humans than yeast, flies, or worms, and they are easier to study than other mammals because of their relatively small size and short life span. Rodent models also allow strict control of many variables that are difficult to control in human studies, and that could affect the trajectory of aging, including diet, life experiences, parity, and pharmaceutical exposures. Furthermore, comparison between the mouse and human genomes suggests that most human genetic diseases could be modeled by changes in equivalent genes in these rodents. Rodent studies have greatly contributed to our understanding of the life lengthening potential of specific genetic mutations, calorie restriction, and a number of drug interventions such as rapamycin, acarbose, and 17alpha-estradiol.

The full potential of rodent models for aging research, however, has been limited by inconsistent reproducibility, which is partly traceable to differences in the environmental conditions the animals experience – laboratory-specific variations in handling, housing, diet, water supply, and noise level, to name a few. This challenge may be even more severe in studies of old animals, for which age-related diseases and loss of resilience can amplify the effects of such factors. Variation among sites in interpretation of IACUC guidelines can also lead to variations in outcome of aging studies.

This 1.5 day meeting is aimed at developing an understanding of current best practices for working with mice and rats for aging research, with the ultimate goal of improving standardization on what is working well, and correcting problem areas that might impede progress in this field. Topics will include: (a) selection of species, strain, and sex for studies of aging; (b) influential effects of husbandry and testing conditions; (c) veterinary care and regulatory issues for aging and aged mice and rats; (e) evaluation and improvement of mouse and rat models for important human late-life diseases; (f) successes and failures of recent attempts for standardization among laboratories.
NLM Title: Optimal Use of Mice and Rats in Aging Research / NIA, NIH.
Author: Optimal Use of Mice and Rats in Aging Research (Meeting)
National Institute on Aging,
Publisher:
Abstract: (CIT): Mice and rats have long been favorite animal models for aging research, because they are more closely related to humans than yeast, flies, or worms, and they are easier to study than other mammals because of their relatively small size and short life span. Rodent models also allow strict control of many variables that are difficult to control in human studies, and that could affect the trajectory of aging, including diet, life experiences, parity, and pharmaceutical exposures. Furthermore, comparison between the mouse and human genomes suggests that most human genetic diseases could be modeled by changes in equivalent genes in these rodents. Rodent studies have greatly contributed to our understanding of the life lengthening potential of specific genetic mutations, calorie restriction, and a number of drug interventions such as rapamycin, acarbose, and 17alpha-estradiol. The full potential of rodent models for aging research, however, has been limited by inconsistent reproducibility, which is partly traceable to differences in the environmental conditions the animals experience - laboratory-specific variations in handling, housing, diet, water supply, and noise level, to name a few. This challenge may be even more severe in studies of old animals, for which age-related diseases and loss of resilience can amplify the effects of such factors. Variation among sites in interpretation of IACUC guidelines can also lead to variations in outcome of aging studies. This 1.5 day meeting is aimed at developing an understanding of current best practices for working with mice and rats for aging research, with the ultimate goal of improving standardization on what is working well, and correcting problem areas that might impede progress in this field. Topics will include: (a) selection of species, strain, and sex for studies of aging; (b) influential effects of husbandry and testing conditions; (c) veterinary care and regulatory issues for aging and aged mice and rats; (e) evaluation and improvement of mouse and rat models for important human late-life diseases; (f) successes and failures of recent attempts for standardization among laboratories.
Subjects: Aging
Animal Experimentation
Biomedical Research--methods
Mice
Models, Animal
Rats
Publication Types: Congress
Webcast
 
NLM Classification: WT 20
NLM ID: 101760364
CIT Live ID: 34969
Permanent link: https://videocast.nih.gov/watch=34969