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Putting Together the Human Brain: Lessons from Disease

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Air date: Monday, December 13, 2010, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 151 * This only includes stats from October 2011 and forward.
Category: Neuroscience
Runtime: 00:55:09
Description: Neuroscience Seminar Series

Dr. Gleeson's laboratory studies the genetic and cell biological basis of human brain development, focusing on two major conditions that are important causes of disease in humans. The first is disordered neuronal migration. Neurons that populate the cerebral cortex are not born within the gray matter, but instead they are born along the lining of the lateral ventricle. These young neurons then migrate great distances to achieve proper positioning within the correct lamina of the developing cortex. When this is disrupted, cortical gyri and sulci are malformed and the cortex is improperly laminated. The other condition is congenital ataxia, where humans are born with severe balance disturbances and malformations of the cerebellum. They work on the most common of these disorders known as Joubert syndrome where the cerebellare completely absent. They identified the first genes for this condition, which encode novel proteins. There is evidence to suggest that in this condition the major axonal tracts fail to form properly, suggesting that the genes also play important roles in axonal guidance. The lab is currently studying the molecular basis of Joubert syndrome, identifying additional Jouberin genes, and working to understand the role of these genes in brain development.

http://neuroseries.info.nih.gov
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NLM Title: Putting together the human brain : lessons from disease [electronic resource] / Joseph Gleeson.
Author: Gleeson, Joseph.
Publisher:
Abstract: (CIT): Neuroscience Seminar Series Dr. Gleeson's laboratory studies the genetic and cell biological basis of human brain development, focusing on two major conditions that are important causes of disease in humans. The first is disordered neuronal migration. Neurons that populate the cerebral cortex are not born within the gray matter, but instead they are born along the lining of the lateral ventricle. These young neurons then migrate great distances to achieve proper positioning within the correct lamina of the developing cortex. When this is disrupted, cortical gyri and sulci are malformed and the cortex is improperly laminated. The other condition is congenital ataxia, where humans are born with severe balance disturbances and malformations of the cerebellum. They work on the most common of these disorders known as Joubert syndrome where the cerebellare completely absent. They identified the first genes for this condition, which encode novel proteins. There is evidence to suggest that in this condition the major axonal tracts fail to form properly, suggesting that the genes also play important roles in axonal guidance. The lab is currently studying the molecular basis of Joubert syndrome, identifying additional Jouberin genes, and working to understand the role of these genes in brain development.
Subjects: Ataxia--genetics
Brain--physiology
Malformations of Cortical Development, Group II--genetics
Publication Types: Lectures
Webcasts
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NLM Classification: WL 300
NLM ID: 101552198
CIT Live ID: 9777
Permanent link: https://videocast.nih.gov/launch.asp?16338

 

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