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The Ups and Downs of Ocular Dominance Plasticity in Visual Cortex
Monday, April 4, 2005,
12:00:00 PM Time displayed is Eastern Time, Washington DC Local
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Dr. Bear has made and continues to make outstanding and highly significant contributions to neuroscience in the field of synaptic plasticity, learning and memory and developmental plasticity. His work has primarily focused on understanding the roles and mechanisms of long-term synaptic plasticity in hippocampus and visual cortex. In particular he described and characterized long-term depression (LTD) and has identified that this form of plasticity is required during ocular dominance plasticity, providing one of the most convincing and well described roles for long-term synaptic plasticity in the in vivo setting. In addition, Mark has also made numerous important contributions concerning the role of developmental changes in NMDA receptor subunit expression in visual cortex plasticity, the molecular mechanisms of synaptic plasticity, and mechanisms and roles of heterosynaptic plasticity.