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Genes, lifestyle, and risk for heart attack

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Air date: Wednesday, May 22, 2019, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 409, (183 Live, 226 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:02:34
Description: NIH Director's Wednesday Afternoon Lecture Series

Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 95 genetic loci to coronary risk. Large-scale gene-sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology, and informed the development of new therapeutics. Moving forward, genetic testing could enable precision-medicine approaches by identifying subgroups of patients who are at increased risk of coronary artery disease or have a specific driving pathophysiology that would make a therapeutic or preventive approach most useful.

Dr. Kathiresan leverages human genetics to understand the root causes of heart attack and to improve preventive cardiac care. Among his scientific contributions, Dr. Kathiresan has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention.

For more information go to https://oir.nih.gov/wals/2018-2019
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NLM Title: Genes, lifestyle, and risk for heart attack / Sekar Kathiresan.
Author: Kathiresan, Sekar.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Director's Wednesday Afternoon Lecture Series. Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 95 genetic loci to coronary risk. Large-scale gene-sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology, and informed the development of new therapeutics. Moving forward, genetic testing could enable precision-medicine approaches by identifying subgroups of patients who are at increased risk of coronary artery disease or have a specific driving pathophysiology that would make a therapeutic or preventive approach most useful. Dr. Kathiresan leverages human genetics to understand the root causes of heart attack and to improve preventive cardiac care. Among his scientific contributions, Dr. Kathiresan has helped highlight new biological mechanisms underlying heart attack, discovered mutations that protect against heart attack risk, and developed a genetic test for personalized heart attack prevention.
Subjects: Genetic Loci--genetics
Genetic Testing
Models, Genetic
Mutation--genetics
Myocardial Infarction--genetics
Risk Factors
Publication Types: Lecture
Webcasts
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NLM Classification: WG 310
NLM ID: 101749142
CIT Live ID: 31985
Permanent link: https://videocast.nih.gov/launch.asp?27563