Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Dissecting computations in the dopamine reward circuit

Loading video...

279 Views  
   
Air date: Monday, November 9, 2015, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 279, (48 Live, 231 On-demand)
Category: Neuroscience
Runtime: 01:00:22
Description:

NIH Neuroscience Seminar Series

The ability of efficiently acquiring sensory information and selecting an appropriate action is the essence of flexible behaviors. To make good decisions, it is also crucial to evaluate the consequences of previous actions (gains and costs) and adjust strategies for future decisions. Dr. Uchida’s laboratory is interested in neuronal processes by which sensory information and memory about previous experiences guide behavior of the animal. Their main questions are: 1) How is odor information coded and processed by an ensemble of neurons? 2) What kinds of circuit dynamics underlie decision-making processes? 3) What are the mechanisms for learning based on rewards and punishments? They have developed an odor-guided perceptual decision task in rats and mice. This behavioral paradigm was recently combined with a multi-electrode recording technique (tetrodes) which allows them to monitor activity of multiple neurons simultaneously while animals are performing a behavioral task. Particular emphasis will be made on the use of behavior. First, behavioral paradigms specify computations (e.g. extracting relevant information in the sensory stimulus) and behavioral goals (e.g. maximizing rewards in a certain period) to be achieved. This in turn guides the way neuronal activities are analyzed. Furthermore, behavioral experiments are necessary to test relevance of certain activity of neurons or hypothesis about "neural codes" obtained in neuronal recordings. They will use various molecular and genetic tools available in mice to further test specific hypotheses experimentally. By combining the above approaches, they wish to establish a causal link between activity of specific neuronal circuits and the dynamics of behavior and learning.

Debug: Show Debug
NLM Title: Dissecting computations in the dopamine reward circuit / Nao Uchida.
Author: Uchida, Nsao.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): NIH Neuroscience Seminar Series. The ability of efficiently acquiring sensory information and selecting an appropriate action is the essence of flexible behaviors. To make good decisions, it is also crucial to evaluate the consequences of previous actions (gains and costs) and adjust strategies for future decisions. Dr. Uchida"s laboratory is interested in neuronal processes by which sensory information and memory about previous experiences guide behavior of the animal. Their main questions are: 1) How is odor information coded and processed by an ensemble of neurons? 2) What kinds of circuit dynamics underlie decision-making processes? 3) What are the mechanisms for learning based on rewards and punishments? They have developed an odor-guided perceptual decision task in rats and mice. This behavioral paradigm was recently combined with a multi-electrode recording technique (tetrodes) which allows them to monitor activity of multiple neurons simultaneously while animals are performing a behavioral task. Particular emphasis will be made on the use of behavior. First, behavioral paradigms specify computations (e.g. extracting relevant information in the sensory stimulus) and behavioral goals (e.g. maximizing rewards in a certain period) to be achieved. This in turn guides the way neuronal activities are analyzed. Furthermore, behavioral experiments are necessary to test relevance of certain activity of neurons or hypothesis about "neural codes" obtained in neuronal recordings. They will use various molecular and genetic tools available in mice to further test specific hypotheses experimentally. By combining the above approaches, they wish to establish a causal link between activity of specific neuronal circuits and the dynamics of behavior and learning.
Subjects: Computational Biology
Conditioning, Classical
Dopaminergic Neurons--physiology
Reward
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
[64k]  [150k]  [240k]  [440k]  [740k]  [1040k]  [1240k]  [1440k]  [1840k]    How to download a Videocast
Caption Text: Download Caption File
NLM Classification: WL 102.5
NLM ID: 101673095
CIT Live ID: 17415
Permanent link: https://videocast.nih.gov/launch.asp?19306