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Dr. Deisseroth's lecture will report on the development of optogenetics and CLARITY technologies. In the optogenetics domain, he will discuss strategies for targeting microbial opsins and light to meet the challenging constraints of the freely-behaving mammal, newly engineered microbial opsin genes spanning a range of optical, kinetic, and ion permeability properties, high-speed behavioral and neural activity-readout tools compatible with real-time optogenetic control, and the application of these tools to develop circuit-based insights into anxiety, depression, and motivated behaviors. Dr. Deisseroth will also discuss advances in the CLARITY technology that accelerate the extraction of information from intact biological tissue (mouse and human brain tissue) that has been transformed resulting in a transparent tissue-hydrogel that preserves and makes accessible, structural and molecular information for visualization and analysis. Together these complementary approaches can be used to probe disease mechanisms as well as the structure of the nervous system.
About the Annual Marshall W. Nirenberg Lecture:
The lecture, established in 2011, honors Marshall Nirenberg for deciphering the genetic code, which resulted in his sharing the 1968 Nobel Prize in Physiology or Medicine. Dr. Nirenberg's career at NIH spanned more than 50 years and his later research focused on neuroscience, with particular emphasis on neural development. The Nirenberg lecture recognizes scientists who have made outstanding contributions to genetics and molecular biology.
For more information go to http://wals.od.nih.gov
Karl Deisseroth, M.D., Ph.D., Investigator, Howard Hughes Medical Institute; D.H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences, Stanford University