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Optogenetics: Development and Application

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Air date: Monday, February 13, 2012, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 854, (101 Live, 753 On-demand)
Category: Neuroscience
Runtime: 01:05:19
Description: Neuroscience Seminar Series

Dr. Deisseroth's lab has developed and applied optogenetic methods based on microbial opsin genes, to achieve gain- or loss-of-function of well-defined events within specific cells of living tissue, including freely moving mammals. This talk will cover their recent efforts on optogenetics, including the crystal structure of channelrhodopsin, recent genomic and molecular engineering work to expand the microbial opsin toolkit, the development of novel optogenetic hardware and techniques (based on optical imaging, ofMRI, electrophysiology, and behavior) for control and readout of neural activity, and a number of optogenetic applications relevant to neuropsychiatric disease, spanning anxiety, social behavior dysfunction, fear memory recall, drug abuse, and depression.

For more information, visit: http://neuroseries.info.nih.gov
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NLM Title: Optogenetics : development and application [electronic resource] / Karl Deisseroth.
Series: Neuroscience seminar series
Author: Deisseroth, Karl.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Neuroscience seminar series
Abstract: (CIT): Dr. Deisseroth's lab has developed and applied optogenetic methods based on microbial opsin genes, to achieve gain- or loss-of-function of well-defined events within specific cells of living tissue, including freely moving mammals. This talk will cover their recent efforts on optogenetics, including the crystal structure of channelrhodopsin, recent genomic and molecular engineering work to expand the microbial opsin toolkit, the development of novel optogenetic hardware and techniques (based on optical imaging, of MRI, electrophysiology, and behavior) for control and readout of neural activity, and a number of optogenetic applications relevant to neuropsychiatric disease, spanning anxiety, social behavior dysfunction, fear memory recall, drug abuse, and depression.
Subjects: Fiber Optic Technology
Nerve Tissue Proteins--physiology
Neural Pathways--physiology
Opsins--genetics
Prefrontal Cortex--physiology
Rhodopsin--genetics
Publication Types: Lectures
Webcasts
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NLM Classification: WL 307
NLM ID: 101581445
CIT Live ID: 10766
Permanent link: https://videocast.nih.gov/launch.asp?17106