NIH VideoCast - NIH COVID-19 Lecture: COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far

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NIH COVID-19 Lecture: COVID-19 Autopsy Findings: A Joint Effort Between NYU Winthrop Hospital and NCI — What Have We Learned So Far

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Air date:	Wednesday, July 22, 2020, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 1,662 (919 Live, 743 On-demand)
Category:	COVID-19
Runtime:	01:03:18
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH COVID-19 Lecture Series Since the outbreak of COVID-19 disease, caused by SARS-CoV-2 infection, many studies focusing on clinical course, outcome, clinical parameters, prognostic markers, treatment strategies have been published. Although most patients experience mild symptoms, some have serious complications—including diffuse alveolar damage, hemodynamic shock, acute kidney failure, cardiac injury, and arrhythmia—that contribute to the high mortality rate. Autopsies can offer a better understanding of the underlying pathophysiology. Unfortunately few autopsies were performed early in the pandemic because of the potential risks. Untreated patients who died of SARS-CoV-2 were rarely autopsied. Most of the published autopsy studies have focused on lung disease with a few describing findings in other organs. We will discuss our experience with the first set of patient autopsies performed at NYU Winthrop Hospital as well as some of our own experience here at the NIH. We will review some of the key findings in major organ systems accompanied by immunohistochemical and in situ hybridization studies that examined some of the cytokines/chemokines that have been implicated in the pathogenesis of this viral infection.

NLM Title:	COVID-19 autopsy findings : a joint effort between NYU Winthrop Hospital and NCI -- what have we learned so far / Stefania Pittaluga, David Kleiner.
Author:	Pittaluga, Stefania. Kleiner, David Erwin. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): NIH COVID-19 Lecture Series. Since the outbreak of COVID-19 disease, caused by SARS-CoV-2 infection, many studies focusing on clinical course, outcome, clinical parameters, prognostic markers, treatment strategies have been published. Although most patients experience mild symptoms, some have serious complications--including diffuse alveolar damage, hemodynamic shock, acute kidney failure, cardiac injury, and arrhythmia--that contribute to the high mortality rate. Autopsies can offer a better understanding of the underlying pathophysiology. Unfortunately few autopsies were performed early in the pandemic because of the potential risks. Untreated patients who died of SARS-CoV-2 were rarely autopsied. Most of the published autopsy studies have focused on lung disease with a few describing findings in other organs. We will discuss our experience with the first set of patient autopsies performed at NYU Winthrop Hospital as well as some of our own experience here at the NIH. We will review some of the key findings in major organ systems accompanied by immunohistochemical and in situ hybridization studies that examined some of the cytokines/chemokines that have been implicated in the pathogenesis of this viral infection.
Subjects:	Autopsy Coronavirus Infections--etiology Coronavirus Infections--physiopathology Cytokines--physiology Immunohistochemistry In Situ Hybridization Pandemics Pneumonia, Viral--physiopathology
Publication Types:	Lecture Webcast

NLM Classification:	WC 505
NLM ID:	101770498
CIT Live ID:	38104
Permanent link:	https://videocast.nih.gov/watch=38104

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