NIH VideoCast - Encoding and scaling pain through specific cell types

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Encoding and scaling pain through specific cell types

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Air date:	Monday, November 6, 2017, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 249 (24 Live, 225 On-demand)
Category:	Neuroscience
Runtime:	00:54:12
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	NIH Neuroscience Series Seminar Two main directions of research are conducted in Dr. Ernfors group - understanding how complex sets of modality specific sensory neurons codes for somatic sensation and understanding the biology of glioblastoma. The problem of pain continues to grow as population age, but there has been a difficulty to develop new useful analgesic drugs. Almost 1 in 5 of the population has an ongoing pain problem, with 7% suffering debilitating pain. Little remains known regarding the actual cellular and molecular complexity during pain transduction, simply because of lack of knowledge on the sensory neuron types conducting somatosensation and pain. A major focus of the lab is to determine the full cellular and molecular complexity of pain and unravel the critical cell types driving pain in particular types of pain disorders. For this purpose, they are using unbiased identification and classification of sensory cell types in rodents and non-human primates and exploit this knowledge to reveal their participation in acute, inflammatory and neuropathic pain using mouse genetics. Hence, the overall aim is to provide knowledge on the existence of defined types of nociceptive cells and assign their participation to particular types of pain states. For more information go to https://neuroscience.nih.gov/neuroseries/Home.aspx

NLM Title:	Encoding and scaling pain through specific cell types / Patrik Ernfors.
Author:	Ernfors, Patrik. National Institutes of Health (U.S.),
Publisher:
Abstract:	(CIT): Two main directions of research are conducted in Dr. Ernfors group - understanding how complex sets of modality specific sensory neurons codes for somatic sensation and understanding the biology of glioblastoma. The problem of pain continues to grow as population age, but there has been a difficulty to develop new useful analgesic drugs. Almost 1 in 5 of the population has an ongoing pain problem, with 7% suffering debilitating pain. Little remains known regarding the actual cellular and molecular complexity during pain transduction, simply because of lack of knowledge on the sensory neuron types conducting somatosensation and pain. A major focus of the lab is to determine the full cellular and molecular complexity of pain and unravel the critical cell types driving pain in particular types of pain disorders. For this purpose, they are using unbiased identification and classification of sensory cell types in rodents and non-human primates and exploit this knowledge to reveal their participation in acute, inflammatory and neuropathic pain using mouse genetics. Hence, the overall aim is to provide knowledge on the existence of defined types of nociceptive cells and assign their participation to particular types of pain states.
Subjects:	Nociceptive Pain--physiopathology Nociceptors--physiology Pain Measurement
Publication Types:	Lecture Webcast

NLM Classification:	WL 704
NLM ID:	101718210
CIT Live ID:	24847
Permanent link:	https://videocast.nih.gov/watch=24847

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