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The Various Roles of Nanoscale AMPA Receptor Dynamics in Synaptic Plasticity

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Air date: Monday, February 6, 2017, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 208, (29 Live, 179 On-demand)
Category: Neuroscience
Runtime: 01:11:49
Description: NIH Neuroscience Series

Robert Newcomb Memorial Seminar

Dr. Choquet’s lab has a transdisciplinary approach to study the interplay between the organizational dynamics of the molecular components of glutamatergic synapses and synaptic transmission. Their projects build on their recent findings that: trafficking of neuronal molecules such as glutamate receptors is highly dynamic, regulations of protein-protein interactions play key roles in the control of this trafficking at different steps, including lateral diffusion, endo and exocytosis, modulation of glutamate receptor trafficking has a profound impact on synaptic transmission, including on both short and long term post-synaptic plasticity.

By combining the expertise of chemists, biochemists, cell biologists, biophysicists and neurophysiologists, they will develop 3 main research axes: dynamics and physical-chemistry of the macro-molecular complexes of the synapse, nano-scale organization and dynamics of synaptic proteins and membrane trafficking, impact of the dynamic of synapse organization on synaptic physiology.

Results obtained in these three axes will be constantly integrated to provide a global view of glutamatergic synapse physiology, from nano-scale interactions to function.

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Author: Daniel Choquet, Ph.D., Researcher, Interdisciplinar Institute of Neuroscience, University of Bordeaux
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CIT Live ID: 19836
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