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Controlling innate T cell development in the thymus by cytokine receptor signaling

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Air date: Friday, October 28, 2016, 12:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 118, (44 Live, 74 On-demand)
Category: NIH Director's Seminars
Runtime: 00:56:03
Description: Director's Seminar Series

T cells are generated in the thymus and then exported into the periphery where they undergo further maturation and differentiation into effector T cells. Lineage choice into distinct effector T cell subsets is tightly controlled by cytokine signaling. Specifically, cytokines of the common g-chain (gc) family play critical roles in cell fate decision and acquisition of effector function. Conventionally, effector T cell generation has been viewed as a process limited to peripheral tissues. Recent reports, however, revealed that the thymus also produces effector T cells, and that these cells are phenotypically mature and functionally competent without having encountered antigens. Thymus-derived innate phenotype T cells include, among others, NKT cells, a subset of gd T cells and IFN-g producing innate CD8 T cells. Analogous to their peripheral counterparts, thymus-generated effector T cells also require cytokine signaling for lineage choice and effector function. Unlike peripheral effector T cells, however, the molecular basis for cytokine-driven lineage choice and effector molecule expression remains largely unknown. Here we address the role of gc cytokines in thymic NKT subset differentiation, and reveal a role for the IL-4 receptor/STAT6 axis in controlling cell fate decision of both NKT and innate CD8 T cells. Interrogating the mechanisms of innate effector T cell differentiation is important, as it provides further clues to understand the cellular basis of inflammation, autoimmunity, and other immunological diseases.
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NLM Title: Controlling innate T cell development in the thymus by cytokine receptor signaling / Hyun Park.
Author: Park, Hyun.
National Institutes of Health (U.S.),
Publisher:
Abstract: (CIT): T cells are generated in the thymus and then exported into the periphery where they undergo further maturation and differentiation into effector T cells. Lineage choice into distinct effector T cell subsets is tightly controlled by cytokine signaling. Specifically, cytokines of the common g-chain (gc) family play critical roles in cell fate decision and acquisition of effector function. Conventionally, effector T cell generation has been viewed as a process limited to peripheral tissues. Recent reports, however, revealed that the thymus also produces effector T cells, and that these cells are phenotypically mature and functionally competent without having encountered antigens. Thymus-derived innate phenotype T cells include, among others, NKT cells, a subset of gd T cells and IFN-g producing innate CD8 T cells. Analogous to their peripheral counterparts, thymus-generated effector T cells also require cytokine signaling for lineage choice and effector function. Unlike peripheral effector T cells, however, the molecular basis for cytokine-driven lineage choice and effector molecule expression remains largely unknown. Here we address the role of gc cytokines in thymic NKT subset differentiation, and reveal a role for the IL-4 receptor/STAT6 axis in controlling cell fate decision of both NKT and innate CD8 T cells. Interrogating the mechanisms of innate effector T cell differentiation is important, as it provides further clues to understand the cellular basis of inflammation, autoimmunity, and other immunological diseases.
Subjects: Cell Differentiation
Natural Killer T-Cells--metabolism
Receptors, Cytokine--metabolism
Signal Transduction
Thymus Gland--cytology
Publication Types: Lectures
Webcasts
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NLM Classification: WH 200
NLM ID: 101697703
CIT Live ID: 20177
Permanent link: https://videocast.nih.gov/launch.asp?19964