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Wizardry of Tissue Repair and Regeneration: A Tale of Skin Cells when their Magic is all but Gone

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Air date: Wednesday, March 7, 2012, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 417, (3 Live, 414 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:06:48
Description: Current research focus of Dr. Tomic-Canic is molecular and cellular mechanisms of wound healing and its inhibition with the long-term goal to bring bench-side research back to patients at the bedside. Her research includes human and diabetic models of wound healing, wound genomics analyses, generating primary cells from patients’ wound biopsies, local sustained gene delivery, cellular assays of wound healing, and histology and immunohistochemistry of skin. Dr. Tomic-Canic and her colleagues, supported in part by NINR, made several fundamental discoveries in the field of wound healing research. These discoveries include identification of the one of the first genes and unique molecular pathway that stops wounds from healing; a novel molecular mechanism though which corticosteroids inhibit wound healing; biomarkers that can guide the extent surgical debridement; establishment of human wound tissue/cell bank; new drugs that accelerate healing. Dr Tomic-Canic has an established track record of successfully bringing basic science discovery to clinical use for wound patients. Her lab has identified molecular markers that may predict clinical outcome of non-healing and guide surgical debridement of chronic ulcers, which are currently being validated in an NIH-sponsored clinical trial.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

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NLM Title: Wizardry of tissue repair and regeneration : a tale of skin cells when their magic is all but gone [electronic resource] / Marjana Tomic-Canic.
Series: Wednesday afternoon lecture series
Author: Tomic-Canic, Marjana.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Wednesday afternoon lecture series
Abstract: (CIT): Current research focus of Dr. Tomic-Canic is molecular and cellular mechanisms of wound healing and its inhibition with the long-term goal to bring bench-side research back to patients at the bedside. Her research includes human and diabetic models of wound healing, wound genomics analyses, generating primary cells from patients" wound biopsies, local sustained gene delivery, cellular assays of wound healing, and histology and immunohistochemistry of skin. Dr. Tomic-Canic and her colleagues, supported in part by NINR, made several fundamental discoveries in the field of wound healing research. These discoveries include identification of the one of the first genes and unique molecular pathway that stops wounds from healing; a novel molecular mechanism though which corticosteroids inhibit wound healing; biomarkers that can guide the extent surgical debridement; establishment of human wound tissue/cell bank; new drugs that accelerate healing. Dr Tomic-Canic has an established track record of successfully bringing basic science discovery to clinical use for wound patients. Her lab has identified molecular markers that may predict clinical outcome of non-healing and guide surgical debridement of chronic ulcers, which are currently being validated in an NIH-sponsored clinical trial.
Subjects: Skin
Wound Healing--physiology
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
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Caption Text: Download Caption File
NLM Classification: WO 185
NLM ID: 101581473
CIT Live ID: 10497
Permanent link: https://videocast.nih.gov/launch.asp?17147

 

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