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Virus Clearance: It Isn't Easy

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Air date: Wednesday, November 30, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 375, (120 Live, 255 On-demand)
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:09:57
Description: Viruses can cause acute, latent or persistent infections depending on the effectiveness of the immune response in clearance of the virus from sites of infection. Clearance of acute RNA virus infections is generally thought to occur by cytolytic mechanisms within a few days. Our studies of alphavirus encephalitis have shown that clearance of infectious virus from the infected neurons is complete 7-8 days after infection, but that clearance of viral RNA occurs over many weeks and is never complete. Suppression of virus reactivation requires long-term residence of immune cells in the brain and spinal cord. Likewise, our studies of measles virus infection has shown that infectious virus is cleared within 1-2 days after the rash has faded, but clearance of viral RNA from peripheral blood mononuclear cells and lymphoid tissues is ongoing for several months. These findings may help to explain slow resolution of symptoms, prolonged immune suppression and late appearance of disease associated with persistent infection.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information, visit:
The NIH Director's Wednesday Afternoon Lecture Series
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NLM Title: Virus clearance : it isn't easy [electronic resource] / Diane E. Griffin.
Series: NIH Wednesday afternoon lecture
Author: Griffin, Diane E.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH Wednesday afternoon lecture
Abstract: (CIT): Viruses can cause acute, latent or persistent infections depending on the effectiveness of the immune response in clearance of the virus from sites of infection. Clearance of acute RNA virus infections is generally thought to occur by cytolytic mechanisms within a few days. Our studies of alphavirus encephalitis have shown that clearance of infectious virus from the infected neurons is complete 7-8 days after infection, but that clearance of viral RNA occurs over many weeks and is never complete. Suppression of virus reactivation requires long-term residence of immune cells in the brain and spinal cord. Likewise, our studies of measles virus infection has shown that infectious virus is cleared within 1-2 days after the rash has faded, but clearance of viral RNA from peripheral blood mononuclear cells and lymphoid tissues is ongoing for several months. These findings may help to explain slow resolution of symptoms, prolonged immune suppression and late appearance of disease associated with persistent infection.
Subjects: RNA Virus Infections--immunology
RNA Virus Infections--virology
RNA Viruses--immunology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: QW 168
NLM ID: 101574501
CIT Live ID: 10508
Permanent link: https://videocast.nih.gov/launch.asp?16998

 

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