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Human Pluripotent Stem Cells: Tools for Cardiovascular Medicine

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Air date: Tuesday, September 6, 2011, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 272 * This only includes stats from October 2011 and forward.
Category: Stem Cell
Runtime: 01:01:52
Description: Human embryonic stem cells (ESCs) and human induce pluripotent stem cells (iPSCs) can provide theoretically unlimited supplies of human cardiac myocytes(CMs) for research and potentially clinical applications. Furthermore, generation of iPSCs from genetically diverse samples will enable creation of libraries of iPSCs that will better reflect the genetic diversity of the population as well as generate disease-specific models.

However, the promise of these unique cells is only starting to be realized as technical roadblocks are overcome and proof-of-principle studies are undertaken. For example, the differentiation of human pluripotent stem cells to cardiomyocytes has been highly inefficient, but here we will described a novel approach using extracellular matrix in combination with growth factors to produce in high yield and purity CMs.

The presentation will also describe the use of human iPSCs to model Pompe Disease and Long QT syndrome. The final section will describe a unique cardiac progenitor cell population that we have isolated using the SRF-cardiac specific enhancer which may prove useful in cardiac repair.
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NLM Title: Human pluripotent stem cells : tools for cardiovascular medicine [electronic resource] / Timothy J. Kamp.
Series: NIH CRM/SCIG stem cell seminar
Author: Kamp, Timothy J.
National Institutes of Health (U.S.). Stem Cell Interest Group.
Publisher:
Other Title(s): NIH CRM/SCIG stem cell seminar
Abstract: (CIT): Human embryonic stem cells (ESCs) and human induce pluripotent stem cells (iPSCs) can provide theoretically unlimited supplies of human cardiac myocytes(CMs) for research and potentially clinical applications. Furthermore, generation of iPSCs from genetically diverse samples will enable creation of libraries of iPSCs that will better reflect the genetic diversity of the population as well as generate disease-specific models. However, the promise of these unique cells is only starting to be realized as technical roadblocks are overcome and proof-of-principle studies are undertaken. For example, the differentiation of human pluripotent stem cells to cardiomyocytes has been highly inefficient, but here we will described a novel approach using extracellular matrix in combination with growth factors to produce in high yield and purity CMs. The presentation will also describe the use of human iPSCs to model Pompe Disease and Long QT syndrome. The final section will describe a unique cardiac progenitor cell population that we have isolated using the SRF-cardiac specific enhancer which may prove useful in cardiac repair.
Subjects: Cell Differentiation--physiology
Embryonic Stem Cells--physiology
Glycogen Storage Disease Type II
Induced Pluripotent Stem Cells--physiology
Long QT Syndrome
Myocytes, Cardiac--cytology
Publication Types: Lectures
Webcasts
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Caption Text: Download Caption File
NLM Classification: WG 280
NLM ID: 101571659
CIT Live ID: 10533
Permanent link: https://videocast.nih.gov/launch.asp?16831