Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Bound and Determined: Cell Fate in Health and Disease

Loading video...

 
   
Air date: Wednesday, June 15, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 103 * This only includes stats from October 2011 and forward.
Category: WALS - Wednesday Afternoon Lectures
Runtime: 01:04:01
Description: We have previously shown that mice lacking the adaptor protein Schnurri-3 display a profound high bone mass phenotype due to augmented anabolic bone formation. In addition to regulating bone formation by osteoblasts in a cell-intrinsic manner, Shn3 indirectly controls bone resorption in vivo. In most instances, bone formation is coupled with bone resorption, which limits the efficacy of the currently marked anti-resorptives. However, in this instance, we demonstrate that these two processes can be uncoupled by genetic manipulation of Shn3 raising the possibility that its inhibition would be beneficial in the setting of diseases of low bone mass such as osteoporosis. We have recently used both unbiased and Schnurri-3 biased forward genetic RNAi screens coupled with extensive gene profiling analyses to assemble a picture of osteoblast signaling pathways proximal to or instigated by Schnurri3. These analyses have provided novel targets in osteoblasts that control adult bone mass.

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

For more information, visit:
The NIH Director's Wednesday Afternoon Lecture Series
Debug: Show Debug
NLM Title: Bound and determined : cell fate in health and disease [electronic resource] / Laurie Glimcher.
Series: NIH director's Wednesday afternoon lecture series
Author: Glimcher, Laurie.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): NIH director's Wednesday afternoon lecture series
Abstract: (CIT): We have previously shown that mice lacking the adaptor protein Schnurri-3 display a profound high bone mass phenotype due to augmented anabolic bone formation. In addition to regulating bone formation by osteoblasts in a cell-intrinsic manner, Shn3 indirectly controls bone resorption in vivo. In most instances, bone formation is coupled with bone resorption, which limits the efficacy of the currently marked anti-resorptives. However, in this instance, we demonstrate that these two processes can be uncoupled by genetic manipulation of Shn3 raising the possibility that its inhibition would be beneficial in the setting of diseases of low bone mass such as osteoporosis. We have recently used both unbiased and Schnurri-3 biased forward genetic RNAi screens coupled with extensive gene profiling analyses to assemble a picture of osteoblast signaling pathways proximal to or instigated by Schnurri3. These analyses have provided novel targets in osteoblasts that control adult bone mass. The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series.
Subjects: Bone and Bones--metabolism
DNA-Binding Proteins
Immunity, Cellular
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
[256k]  [512k]    How to download a Videocast
NLM Classification: WE 200
NLM ID: 101565225
CIT Live ID: 10297
Permanent link: https://videocast.nih.gov/launch.asp?16717

 

Podcast information
Audio Podcasts   Video Podcasts
  Description Runtime     Description Runtime
Listen to the podcast Audio Podcast 01:04:08   Watch the podcast Video Podcast 01:04:08