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Stem cell approaches to understanding lung injury repair and lung cancer

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Air date: Tuesday, June 7, 2011, 2:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 239 * This only includes stats from October 2011 and forward.
Category: Stem Cell
Runtime: 00:57:08
Description: NCRM/SCIG Stem Cell Seminar Series: The broad interest of the Kim laboratory is to characterize the biology of stem cells in normal lung tissue and in lung disease. Carla Kim was the first person to develop a method to isolate a stem cell population from the adult murine lung, termed bronchioalveolar stem cells (BASCs), opening new avenues for understanding lung biology and disease.

They hypothesize that BASCs play an important role in lung injury repair and may be the targets in some forms of lung disease that involve injured or depleted bronchiolar and alveolar cells. Her lab is currently developing transgenic mouse strains and transplantation protocols to test the function of BASCs and other putative lung stem cells in vivo.

They are also engaged in comparative microarray gene expression studies to identify novel molecular markers for BASCs, bronchiolar and alveolar cells. Her lab has recently shown that epigenetic regulation, and specifically the Polycomb group proteins, regulates lung stem cell function. Her research has made important connections between stem cell biology and lung biology that both advance our basic understanding of lung cell complexity and elucidate concepts relevant for human health.
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NLM Title: Stem cell approaches to understanding lung injury repair and lung cancer [electronic resource] / Carla F. Kim.
Series: NCRM/SCIG stem cell seminar series
Author: Kim, Carla F.
National Institutes of Health (U.S.). Stem Cell Interest Group.
Publisher:
Other Title(s): NCRM/SCIG stem cell seminar series
Abstract: (CIT): NCRM/SCIG Stem Cell Seminar Series: The broad interest of the Kim laboratory is to characterize the biology of stem cells in normal lung tissue and in lung disease. Carla Kim was the first person to develop a method to isolate a stem cell population from the adult murine lung, termed bronchioalveolar stem cells (BASCs), opening new avenues for understanding lung biology and disease. They hypothesize that BASCs play an important role in lung injury repair and may be the targets in some forms of lung disease that involve injured or depleted bronchiolar and alveolar cells. Her lab is currently developing transgenic mouse strains and transplantation protocols to test the function of BASCs and other putative lung stem cells in vivo. They are also engaged in comparative microarray gene expression studies to identify novel molecular markers for BASCs, bronchiolar and alveolar cells. Her lab has recently shown that epigenetic regulation, and specifically the Polycomb group proteins, regulates lung stem cell function. Her research has made important connections between stem cell biology and lung biology that both advance our basic understanding of lung cell complexity and elucidate concepts relevant for human health.
Subjects: Adult Stem Cells
Lung Injury
Lung Neoplasms
Lung--cytology
Publication Types: Lectures
Webcasts
Download: To download this event, select one of the available bitrates:
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NLM Classification: WF 600
NLM ID: 101565215
CIT Live ID: 10284
Permanent link: https://videocast.nih.gov/launch.asp?16693