Skip Navigation


CIT can broadcast your seminar, conference or meeting live to a world-wide audience over the Internet as a real-time streaming video. The event can be recorded and made available for viewers to watch at their convenience as an on-demand video or a downloadable podcast. CIT can also broadcast NIH-only or HHS-only content.

Glycoproteomic analysis of HIV envelope proteins, with a focus towards vaccine development

Loading video...

 
   
Air date: Friday, January 11, 2008, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 36 * This only includes stats from October 2011 and forward.
Category: Proteomics
Runtime: 00:59:37
Description: The discovery of an effective vaccine is the best hope to conquer the HIV virus. While current methods in HIV vaccine development span a variety of strategies, one common method is using the virus's own envelope glycoprotein as a vaccine candidate. This molecule is on the viral surface, and it provides the first contact between the virus and cells. Many glycoprotein vaccines are in development for the treatment of HIV, but none of them have passed the critical "efficacy" test in phase III clinical trials. My group hypothesizes that a major problem with the current candidates is the design and control of the carbohydrate portion of these glycoprotein vaccines, since this portion makes up 50% of the mass of the molecule, and very little is known about the "right" carbohydrates needed in the glycoprotein vaccine. We focus on analyzing these moieties using several mass spectrometric methods. By developing the appropriate methods to rapidly screen the carbohydrate content on glycoproteins, and applying these techniques to the glycoprotein on the surface of HIV, we hope to identify critical information needed to generate an effective vaccine against the world's most illusive virus. This seminar will focus on our current successes and future goals in this endeavor.

http://proteome.nih.gov
Debug: Show Debug
NLM Title: Glycoproteomic analysis of HIV envelope proteins, with a focus towards vaccine development [electronic resource] / Heather Desaire.
Series: Glycoprotein analysis for AIDS vaccine development
Author: Desaire, Heather.
National Institutes of Health (U.S.)
Publisher:
Other Title(s): Glycoprotein analysis for AIDS vaccine development
Abstract: (CIT): The discovery of an effective vaccine is the best hope to conquer the HIV virus. While current methods in HIV vaccine development span a variety of strategies, one common method is using the virus's own envelope glycoprotein as a vaccine candidate. This molecule is on the viral surface, and it provides the first contact between the virus and cells. Many glycoprotein vaccines are in development for the treatment of HIV, but none of them have passed the critical "efficacy" test in phase III clinical trials. My group hypothesizes that a major problem with the current candidates is the design and control of the carbohydrate portion of these glycoprotein vaccines, since this portion makes up 50% of the mass of the molecule, and very little is known about the "right" carbohydrates needed in the glycoprotein vaccine. We focus on analyzing these moieties using several mass spectrometric methods. By developing the appropriate methods to rapidly screen the carbohydrate content on glycoproteins, and applying these techniques to the glycoprotein on the surface of HIV, we hope to identify critical information needed to generate an effective vaccine against the world's most illusive virus. This seminar will focus on our current successes and future goals in this endeavor.
Subjects: AIDS Vaccines--immunology
Drug Design
Glycoproteins--immunology
Publication Types: Lectures
Webcasts
Rights: This is a work of the United States Government.
Download: To download this event, select one of the available bitrates:
[384k]    How to download a Videocast
NLM Classification: WC 503.6
NLM ID: 101465432
CIT Live ID: 6277
Permanent link: https://videocast.nih.gov/launch.asp?14231