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Emerging Role of Mass Spectrometry in Structure Elucidation of Cellular Complexes

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Air date: Friday, November 3, 2006, 10:00:00 AM
Time displayed is Eastern Time, Washington DC Local
Views: Total views: 88 * This only includes stats from October 2011 and forward.
Category: Proteomics
Runtime: 00:48:05
Description: High throughput proteomic approaches have identified numerous in vivo protein complexes and suggested the existence of many others from extensive protein interaction networks. Standard proteomics techniques are however unable to describe the stoichiometry, subunit interactions and organisation of these assemblies since many are heterogeneous, present at low cellular abundance and frequently difficult to isolate. We have developed mass spectrometry of non-covalent complexes for the study of novel protein assemblies isolated directly from the cellular environment. This approach is yielding not only detailed information about subunit stoichiometry, composition and dynamic interactions but also the overall architecture of multiprotein complexes.

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Author: Michal Sharon, PhD Department of Chemistry, Cambridge University
Rights: This is a work of the United States Government.
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CIT Live ID: 5482
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