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Glutamatergic Synaptogenesis in the Developing Visual Pathway
Monday, March 7, 2005,
12:00:00 PM Time displayed is Eastern Time, Washington DC Local
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Neural activity optimizes developing brain circuits for the environment in which the organism finds itself. This is one of the most significant evolutionary adaptations in the animal kingdom. Yet it is poorly understood.
Dr. Constantine-Paton’s laboratory is interested in the cellular and molecular mechanisms of this activity-dependent development in vertebrates. They want to know: What functional synaptic behaviors are essential to this process? How are these functions changed, regulated or compensated for as the density of synapses and the patterns of activity shift with development? Finally, what are the consequences of developmental local circuit change in one region of the brain for the integration of that circuit into the ongoing differentiation of brain function, and behavior, as a whole?