Structure And Function Of The Nicotinic Receptor: Insights From Mutagenesis, Structural Modeling And Single Channel Recording

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Air date:	Monday, May 6, 2002, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 93 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	01:10:59
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	The NIH Neuroscience Lecture Series features lectures and discussions with leading neuroscientists. Dr. Sine studies nicotinic receptors at the neuromuscular junction and in the brain. His work is focussed on understanding how agonist binding is transduced into opening of the ion channel intrinsic. In collaboration with Andy Engle he has studied the molecular mechanisms of congenital myasthenic syndromes, diseases that produce profound muscle weakness. Their work has shown that many of these syndromes result from mutations in nicotinic receptors. Analysis of changes in Ach receptor function produced by these mutations is giving profound insight into the gating mechanism, revealing novel sites of regulation that in all probability would not have been discovered were it not for the fact they were identified in myasthenic patients. For more information, visit the NIH Neuroscience Seminar Series

NLM Title:	Structure and function of the nicotinic receptor : insights from mutagenesis, structural modeling and single channel recording / Steven Sine.
Author:	Sine, Steven. National Institutes of Health (U.S.)
Publisher:
Subjects:	Models, Biological Receptors, Nicotinic Synaptic Transmission
Publication Types:	Lecture Webcast
Rights:	This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
NLM Classification:	WL 102.8
NLM ID:	101267878
CIT Live ID:	1045
Permanent link:	https://videocast.nih.gov/watch=1045

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