||The NIH Director's Wednesday Afternoon Lecture Series
Arvid Carlsson, M.D., Ph.D.
Nobel Laureate 2000, Carlsson Research, Inc.
Professor Emeritus of Pharmacology
University of Goteborg, Sweden
In 1956 Carlsson et al. discovered the catecholamine-depleting action of reserpine in tissues, and then discovered the reversal of reserpine- induced akinesia by DOPA. They developed a specific method for detection of dopamine, identified dopamine, demonstrated its unique distribution in the brain. and a proposed a role for dopamine in Parkinson's disease. These studies laid the groundwork for the discovery of dopamine depletion in Parkinson's disease and for the treatment with L-DOPA.
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Arvid Carlsson – Curriculum Vitae