A Prokaryotic Perspective on Pentameric Ligand Gated Ion Channel Structure and Function

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Air date:	Monday, June 7, 2010, 11:00:00 AM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 148 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	01:03:04
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Dr. Dutzler's research group is interested in the mechanisms of transmembrane ion transport. The group takes a multidisciplinary approach combining biochemistry X-ray crystallography and electrophysiology to study the structure and function of ion channels and ion transporters. Dr. Dutzler has solved original x-ray structures of bacterial homologs of several important transporter classes, including the ClC family of chloride channels and transporters and the cys-loop family of neurotransmitter receptors. These structures have yielded important mechanistic insights into both classes of proteins. In addition, Dr. Dutzler's group has used novel combinations of structural and biochemical approaches to obtain functional information regarding these transport proteins. NIH Neuroscience Seminar Series

NLM Title:	A prokaryotic perspective on pentameric ligand gated ion channel structure and function / Raimund Dutzler.
Author:	Dutzler, Raimund. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Dr. Dutzler's research group is interested in the mechanisms of transmembrane ion transport. The group takes a multidisciplinary approach combining biochemistry X-ray crystallography and electrophysiology to study the structure and function of ion channels and ion transporters. Dr. Dutzler has solved original x-ray structures of bacterial homologs of several important transporter classes, including the ClC family of chloride channels and transporters and the cys-loop family of neurotransmitter receptors. These structures have yielded important mechanistic insights into both classes of proteins. In addition, Dr. Dutzler's group has used novel combinations of structural and biochemical approaches to obtain functional information regarding these transport proteins.
Subjects:	Ion Channel Gating--physiology Ion Channels--chemistry Ion Channels--physiology Ligands Prokaryotic Cells
Publication Types:	Lecture Webcast
NLM Classification:	QU 55.7
NLM ID:	101535265
CIT Live ID:	8591
Permanent link:	https://videocast.nih.gov/watch=8591

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