Microtubule Motors and Axonal Transport: Function and Dysfunction in Neurodegenerative Disease

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Air date:	Monday, March 15, 2010, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 232 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	01:09:35
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Description:	Dr. Holzbaur is interested in the mechanisms of microtubule-based motility. This motility is involved in basic cellular processes such as organelle trafficking, and in more specialized functions such as the transport of vesicles along the extended axonal processes of the neuron. Her laboratory focuses on the motor cytoplasmic dynein and its activator complex dynactin. Dynein function is essential in higher eukaryotes, yet its basic mechanisms of action including coupling to cargo and cellular regulation remain to be determined. Currently Dr. Holzbaur’s lab is focusing on (1) biophysical assays for motor function using single molecule approaches; (2) elucidating the mechanisms driving bidirectional transport along the axon; (3) determining the mechanisms that regulate bidirectional transport; and (4) exploring the link between defects in axonal transport and the development of neuropathogenesis in degenerative diseases such as ALS. NIH Neuroscience Seminar Series

NLM Title:	Microtubule motors and axonal transport : function and dysfunction in neurodegenerative disease / Erika Holzbaur.
Author:	Holzbaur, Erika. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Dr. Holzbaur is interested in the mechanisms of microtubule-based motility. This motility is involved in basic cellular processes such as organelle trafficking, and in more specialized functions such as the transport of vesicles along the extended axonal processes of the neuron. Her laboratory focuses on the motor cytoplasmic dynein and its activator complex dynactin. Dynein function is essential in higher eukaryotes, yet its basic mechanisms of action including coupling to cargo and cellular regulation remain to be determined. Currently Dr. Holzbaur"s lab is focusing on (1) biophysical assays for motor function using single molecule approaches; (2) elucidating the mechanisms driving bidirectional transport along the axon; (3) determining the mechanisms that regulate bidirectional transport; and (4) exploring the link between defects in axonal transport and the development of neuropathogenesis in degenerative diseases such as ALS.
Subjects:	Axonal Transport--physiology Microtubule-Organizing Center--physiology Neurodegenerative Diseases--physiopathology
Publication Types:	Lecture Webcast
NLM Classification:	WL 359
NLM ID:	101528429
CIT Live ID:	8561
Permanent link:	https://videocast.nih.gov/watch=8561

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