NIH VideoCast - Regulation of Inflammation and Immunopathology During Helminth Infections, Colitis, and Airway Allergy

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Regulation of Inflammation and Immunopathology During Helminth Infections, Colitis, and Airway Allergy

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Air date:	Wednesday, February 17, 2010, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 174 * This only includes stats from October 2011 and forward.
Category:	Immunology
Runtime:	00:47:42
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Next week's seminar will be given by MARK WILSON, a creative and highly interactive postdoctoral fellow from NIAID working in the area of inflammation immunology. Mark, a native of the UK, has a dual background in parasitology and allergy (rhinitis). He was able to merge his talents in both fields during his doctoral work at the University of Edinburgh with Rick Maizels. There he addressed the question of how intestinal nematode infection influences the outcome of allergic responses. These studies led to a seminal publication in JEM elucidating a major role for helminth-induced regulatory T cells in suppressing allergic airway inflammation. In later work, he extended these studies by identifying a helminth-induced regulatory B cell population triggered by worms that is able to suppress both experimental allergic and autoimmune diseases. In 2005 Mark joined Tom Wynn's lab in the Immunopathogenesis section of LPD, NIAID as a Visiting Fellow and has used his enormous talent in crossing disciplines, experimental systems and collaborations to take full advantage of his NIH postdoctoral experience. Using several helminth infection models and allergic airway inflammation as a read-out, Mark has elucidated the major role played by IL-10 and the cytokine decoy receptor IL-13Rα2 in suppressing distinct immunopathologic features of asthmatic allergy and helminth-associated fibrosis. In related studies employing intestinal whip-worm infections, he uncovered a potential function for the IL-13 receptor alpha 2 in colitis. In Mark's most recent work he has returned to the study of lung inflammation identifying a novel pathway involved in pulmonary fibrosis with correlative observations in idiopathic pulmonary fibrosis (IPF) patients. During his time at the NIH, Mark has been an enthusiastic member of the NIH immunology community and IIG Steering Committee. Since he is leaving this spring to head his own group at the National Institute for Medical Research (Mill Hill) in London, his upcoming Wednesday IIG seminar will be his "swan song" as an NIH fellow. Come and wish him well and hear about the exciting research program that he has developed during his 5 years working in the Wynn lab. The Immunology Interest Group

NLM Title:	Regulation of inflammation and immunopathology during helminth infections, colitis, and airway allergy / Mark S. Wilson.
Author:	Wilson, Mark S. National Institutes of Health (U.S.). Immunology Interest Group.
Publisher:
Abstract:	(CIT): Next week's seminar will be given by MARK WILSON, a creative and highly interactive postdoctoral fellow from NIAID working in the area of inflammation immunology. Mark, a native of the UK, has a dual background in parasitology and allergy (rhinitis). He was able to merge his talents in both fields during his doctoral work at the University of Edinburgh with Rick Maizels. There he addressed the question of how intestinal nematode infection influences the outcome of allergic responses. These studies led to a seminal publication in JEM elucidating a major role for helminth-induced regulatory T cells in suppressing allergic airway inflammation.
Subjects:	Colitis--immunology Helminthiasis--immunology Helminths--pathogenicity Intestinal Diseases, Parasitic--immunology Respiratory Hypersensitivity--immunology
Publication Types:	Lecture Webcast
NLM Classification:	WC 800
NLM ID:	101525674
CIT Live ID:	8334
Permanent link:	https://videocast.nih.gov/watch=8334

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