1c:{"metadata":[["$","title","0",{"children":"NIH VideoCast - B's, Ts, Tolls and DCs in Systemic Autoimmunity"}],["$","meta","1",{"name":"description","content":"Mark Shlomchik is an outstanding B cell expert with a primary focus on autoimmunity. Mark was first in reporting an antibody-independent role of B cells in autoimmune disease. Stemming from his in-depth analysis of an anti-rheumatoid factor transgenic mouse model, he described the prevalence of somatic hypermutated antibody responses in the absence of germinal centers. He has studied the various stages of B cell development, including the germinal center reaction, plasma cells and memory B cells using a variety of approaches: flow cytometry and expression analysis of specific populations, analysis of antibody sequences and cell imaging. Most recently, he has found divergent roles for TLR9 and TLR7 in the lupus autoimmune disease, and has reported on the use of B cell depletion therapy in treatment for diabetes. Come to hear his talk and give the B cells some love!\n

\nFor more information, visit
\nThe Immunology Interest Group
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\nFor more information, visit
\nThe Immunology Interest Group
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\nFor more information, visit
\nThe Immunology Interest Group
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