NIH VideoCast - Optimizing Calcium Ion Channel Function Exon by Exon and Neuron by Neuron

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Optimizing Calcium Ion Channel Function Exon by Exon and Neuron by Neuron

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Air date:	Monday, December 1, 2008, 12:00:00 PM Time displayed is Eastern Time, Washington DC Local
Views:	Total views: 176 * This only includes stats from October 2011 and forward.
Category:	Neuroscience
Runtime:	01:15:45
Closed captioning:	Check box to display CC outside of the video Note: You can drag the captioning window around and resize it
Description:	Dr. Lipscombe studies the regulation of voltage-gated calcium channels in neurons (http://neuroscience.brown.edu/lipscombe.html ). Diane performed her graduate work at University College London with Professors H.P. Rang and D. Colquhoun. She then moved to Dick Tisen’s laboratory for her postdoctoral studies at Yale, subsequently moving with him to Stanford. In 1990 Diane joined the faculty at Brown University department of Neuroscience where she is now Full Professor. Diane’s research focuses on the mechanisms regulating voltage-gated calcium channels. Her work in Dick Tsien’s lab was groundbreaking, defining the mechanism for presynaptic regulation of synaptic transmission by neuromodulators, showing that this is achieved by actions on presynaptic N-type calcium channels. With the cloning of calcium channel subunits, Diane took advantage of molecular approaches to define a series of novel molecular mechanisms regulating calcium channel function, including mRNA stabilization and alternative splicing. Her recent work shows an hitherto unexpected level of regulation of N-type calcium channel function in neurons that is dependent upon alternative splicing of calcium channel mRNA producing a regulation of G protein-dependent inhibition of the channel. The implications for this work are profound showing that cell type specific alternative splicing serves as a molecular switch to control the sensitivity of N-type calcium channels to neuromodulators. Furthermore, it is likely that this is a more general mechanism regulating calcium channel function producing an unexpected degree of diversity in channel regulation. NIH Neuroscience Seminar Series

NLM Title:	Optimizing calcium ion channel function exon by exon and neuron by neuron / Diane Lipscombe.
Author:	Lipscombe, Diane. National Institutes of Health (U.S.)
Publisher:
Abstract:	(CIT): Dr. Lipscombe studies the regulation of voltage-gated calcium channels in neurons (http://neuroscience.brown.edu/lipscombe.html ). Diane performed her graduate work at University College London with Professors H.P. Rang and D. Colquhoun. She then moved to Dick Tisen"s laboratory for her postdoctoral studies at Yale, subsequently moving with him to Stanford. In 1990 Diane joined the faculty at Brown University department of Neuroscience where she is now Full Professor. Diane"s research focuses on the mechanisms regulating voltage-gated calcium channels. Her work in Dick Tsien"s lab was groundbreaking, defining the mechanism for presynaptic regulation of synaptic transmission by neuromodulators, showing that this is achieved by actions on presynaptic N-type calcium channels. With the cloning of calcium channel subunits, Diane took advantage of molecular approaches to define a series of novel molecular mechanisms regulating calcium channel function, including mRNA stabilization and alternative splicing. Her recent work shows an hitherto unexpected level of regulation of N-type calcium channel function in neurons that is dependent upon alternative splicing of calcium channel mRNA producing a regulation of G protein-dependent inhibition of the channel. The implications for this work are profound showing that cell type specific alternative splicing serves as a molecular switch to control the sensitivity of N-type calcium channels to neuromodulators. Furthermore, it is likely that this is a more general mechanism regulating calcium channel function producing an unexpected degree of diversity in channel regulation. NIH Neuroscience Seminar Series.
Subjects:	Calcium Channels--physiology Neurons--chemistry
Publication Types:	Lecture Webcast
NLM Classification:	QU 55.7
NLM ID:	101493069
CIT Live ID:	7129
Permanent link:	https://videocast.nih.gov/watch=7129

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